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ChemicalBook >> CAS DataBase List >> WOBE437

WOBE437

WOBE437 price.
  • $81 - $632
  • Product name: WOBE437
  • CAS: 2108100-73-6
  • MF: C22H33NO3
  • MW: 359.5
  • EINECS:
  • MDL Number:
  • Synonyms:WOBE437;2,4-Dodecadienamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-, (2E,4E)-;(2E,4E)-N-[2-(3,4-dimethoxyphenyl)ethyl]-2,4-dodecadienamide
Price5 Properties Safety Information Description
5 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • ManufacturerAK Scientific
  • Product number1479EN
  • Product description(2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide
  • Packaging1mg
  • Price$187
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1479EN
  • Product description(2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide
  • Packaging5mg
  • Price$495
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23506
  • Product descriptionWOBE437 ≥97%
  • Packaging1mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23506
  • Product descriptionWOBE437 ≥97%
  • Packaging5mg
  • Price$356
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23506
  • Product descriptionWOBE437 ≥97%
  • Packaging10mg
  • Price$632
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1479EN (2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide 1mg $187 2021-12-16 Buy
AK Scientific 1479EN (2E,4E)-N-[2-(3,4-Dimethoxyphenyl)ethyl]dodeca-2,4-dienamide 5mg $495 2021-12-16 Buy
Cayman Chemical 23506 WOBE437 ≥97% 1mg $81 2024-03-01 Buy
Cayman Chemical 23506 WOBE437 ≥97% 5mg $356 2024-03-01 Buy
Cayman Chemical 23506 WOBE437 ≥97% 10mg $632 2024-03-01 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF: 2.5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml
form :A crystalline solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

WOBE437 is a potent endocannabinoid uptake inhibitor with IC50 values of 10 and 283 nM for arachidonoyl ethanolamide (AEA; ) and 2-arachidonoyl glycerol (2-AG; ) uptake, respectively, in U937 cells. It is greater than 1,000-fold selective for endocannabinoid transporters over fatty acid amide hydrolase (FAAH; ) and the 2-AG hydrolyzing enzymes MAGL, ABHD6, and ABHD12. WOBE437 inhibits AEA uptake in FAAH-deficient HMC-1 human mast cells and Neuro2a mouse neuroblastoma cells (IC50s = 137 and 55 nM, respectively) and reduces AEA uptake by 50% in rat cortical neurons when used at a concentration of 1 μM. It also reduces 2-AG uptake by 40% in Neuro2a cells at a concentration of 5 μM. In vivo, WOBE437 increases AEA and 2-AG levels by 1.5-fold in mouse brain but not peripheral tissues after intraperitoneal administration of a 10 mg/kg dose for seven days. WOBE437 (10 mg/kg) also induces a typical tetrad of hypothermia, catalepsy, analgesia, and hypomotility in mice, indicating it also acts as an indirect cannabinoid (CB) receptor 1 agonist.

Suppliers and manufacturers

BOC Sciences Shanghai Hongye Biotechnology Co. Ltd TargetMol Chemicals Inc.