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MGV354

MGV354 structure

CAS No.: 1852495-86-3

Chemical Name:: MGV354

Synonyms: MGV354;(Rac)-MGV354;MGV354|MGV 354;pressure,drop,intraocular,Guanylate Cyclase,(Rac)MGV354,Inhibitor,activator,topical,(Rac) MGV354,inhibit,sGC,(Rac)-MGV354,(Rac)-MGV-354,ocular

CBNumber:: CB54668179

Molecular Formula:: C35H37N5O3

Molecular Weight:: 575.71

MDL Number:: MFCD32664441

MOL File:: 1852495-86-3.mol

Last updated:2024-07-02 08:55:11

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MGV354 Properties

Boiling point	824.8±65.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
solubility	DMSO : 100 mg/mL (173.70 mM; Need ultrasonic)
pka	3.20±0.25(Predicted)
form	Solid
color	White to off-white

MGV354 Chemical Properties,Uses,Production

Biological Activity

(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively[1].

References

[1]. Ehara T, et al. The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61(6):2552-2570.

MGV354 Preparation Products And Raw materials

Raw materials

Preparation Products

MGV354 Suppliers

Global( 30)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5225	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4296	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9941	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58

MGV354 (Rac)-MGV354 pressure,drop,intraocular,Guanylate Cyclase,(Rac)MGV354,Inhibitor,activator,topical,(Rac) MGV354,inhibit,sGC,(Rac)-MGV354,(Rac)-MGV-354,ocular MGV354|MGV 354 1852495-86-3