ChemicalBook >> CAS DataBase List >>VH-032

VH-032

VH-032 structure

CAS No.: 1448188-62-2

Chemical Name:: VH-032

Synonyms: VHL032;VH-032;L-Prolinamide, N-acetyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

CBNumber:: CB54668649

Molecular Formula:: C24H32N4O4S

Molecular Weight:: 472.6

MDL Number:: MFCD33548811

MOL File:: 1448188-62-2.mol

Last updated:2024-07-02 08:55:11

Request For Quotation

VH-032 Properties

Boiling point	778.5±60.0 °C(Predicted)
Density	1.248±0.06 g/cm3(Predicted)
solubility	DMSO: 200 mg/mL (423.19 mM)
pka	14.07±0.40(Predicted)
form	Solid
color	White to off-white

VH-032 Chemical Properties,Uses,Production

Biological Activity

VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. VH032 is a VHL/HIF-1α interaction inhibitor with a Kd PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. Michael Zengerle, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. [2]. Carles Galdeano, et al. Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. J Med Chem. 2014 Oct 23;57(20):8657-63. [3]. Kwok-Ho Chan, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.

VH-032 Preparation Products And Raw materials

Raw materials

Preparation Products

VH-032 Suppliers

Global( 26)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Zhengzhou Lingzhiyue Technology Co., Ltd	+86-0371-55074660 +86-13783527580	Lingzhiyue@aliyun.com	China	3152	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4296	55
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2988	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9941	58
Heze Development Zone chuangli Chemical Co., Ltd.	+86-530-529 6766，+86-15666160102 15666160102	info@chuangli-chem.com	China	890	55
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	507	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
TargetMol Chemicals Inc.	58
Zhengzhou Lingzhiyue Technology Co., Ltd	58
LEAPCHEM CO., LTD.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai Rechem science Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58
Heze Development Zone chuangli Chemical Co., Ltd.	55
Shanghai Yu Ben Biotechnology Co., Ltd.	58

VH-032 Spectrum

VH-032(1448188-62-2)¹HNMR

VH-032 VHL032 (2S,4R)-1-((S)-2-acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide L-Prolinamide, N-acetyl-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- 1448188-62-2