Chlorguanide Hydrochloride
- CAS No.
- 637-32-1
- Chemical Name:
- Chlorguanide Hydrochloride
- Synonyms
- m4888;3359rp;diguanyl;Paludrin;sn12,837;Chlorguanid;Chloroquanil;Proguanil HCL;ChlorguanideHCl;PROGUANIL HCL IP/BP
- CBNumber:
- CB5488955
- Molecular Formula:
- C11H17Cl2N5
- Molecular Weight:
- 290.19
- MDL Number:
- MFCD01732193
- MOL File:
- 637-32-1.mol
- MSDS File:
- SDS
Melting point | 249-2510C |
---|---|
storage temp. | 2-8°C |
solubility | acetonitrile: water: ~1mg/mL (60/40) |
form | solid |
EWG's Food Scores | 1 |
FDA UNII | R71Y86M0WT |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301 |
Precautionary statements | P301+P330+P331+P310 |
Hazard Codes | T |
Risk Statements | 25 |
Safety Statements | 45 |
RIDADR | 3249 |
WGK Germany | 3 |
RTECS | DU1750000 |
HazardClass | 6.1(b) |
PackingGroup | III |
HS Code | 2925294500 |
Toxicity | LD50 orally in rats: 200 mg/kg (Schmidt) |
Chlorguanide Hydrochloride price More Price(9)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | G7048 | Proguanil hydrochloride ≥95% (HPLC) | 637-32-1 | 10mg | $90 | 2024-03-01 | Buy |
Sigma-Aldrich | 1568040 | Proguanil hydrochloride United States Pharmacopeia (USP) Reference Standard | 637-32-1 | 200mg | $393 | 2024-03-01 | Buy |
Sigma-Aldrich | BP297 | Proguanil hydrochloride British Pharmacopoeia (BP) Reference Standard | 637-32-1 | 100MG | $221 | 2023-06-20 | Buy |
Sigma-Aldrich | PHR1713 | Proguanil hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 637-32-1 | 1g | $173 | 2024-03-01 | Buy |
Sigma-Aldrich | G7048 | Proguanil hydrochloride ≥95% (HPLC) | 637-32-1 | 50mg | $341 | 2024-03-01 | Buy |
Chlorguanide Hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug.
Uses
Chlorguanide Hydrochloride can be intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry.
brand name
Paludrine (Zeneca).
General Description
Proguanil hydrochloride is a biguanide compound, widely used as an antimalarial drug. It exhibits sporontocidal activity, thereby rendering the gametocytes non-infective to the mosquito vector.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain. Mutations in DHFR account for the development of resistant strains.
Chlorguanide Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2255 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 24295 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +8618168183658 | sales1@artkmedchem.com | China | 39009 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8072 | 58 |
View Lastest Price from Chlorguanide Hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-06-18 | Chlorguanide Hydrochloride USP/EP/BP
637-32-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
- Chlorguanide Hydrochloride USP/EP/BP
637-32-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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