Oxolamine
- CAS No.
- 959-14-8
- Chemical Name:
- Oxolamine
- Synonyms
- 683M;683 M;Bredon;AF-438;OXOLAMINE;Ossolamina;BRN 0527181;Oxolamine (base and/or unspecified salts);5-[2-(diethylamino)ethyl]-3-phenyl-1,2,4-oxadiazole;1,2,4-OXADIAZOLE,5-(2-DIETHYLAMINO)ETHYL)-3-PHENYL-
- CBNumber:
- CB5491924
- Molecular Formula:
- C14H19N3O
- Molecular Weight:
- 245.32
- MDL Number:
- MFCD00866857
- MOL File:
- 959-14-8.mol
Melting point | 25°C |
---|---|
Boiling point | bp0.4 127° |
Density | 1.0516 (rough estimate) |
refractive index | 1.5310 (estimate) |
pka | 9.40±0.25(Predicted) |
form | Liquid |
LogP | 2.393 |
CAS DataBase Reference | 959-14-8(CAS DataBase Reference) |
FDA UNII | 90BEA145GY |
ATC code | R05DB07 |
Oxolamine Chemical Properties,Uses,Production
Originator
Bredon,Organon
Uses
Oxolamine is a antiinflammatory drug used as a cough suppressant.
Definition
ChEBI: N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine is an oxadiazole and a ring assembly.
Manufacturing Process
18.7 g 3-chloro-propionyl chloride in 50 ml of dry ether was added dropwise with stirring to the cooled with ice solution 40 g of N-hydroxybenzamidine in 450 ml dry ester. A dense precipitate had fallen. The mixture was stirred 0.5 hour at room temperature and then was filtered off. The precipitate was thoroughly washed with water for a removal hydrochloride of starting Nhydroxybenzamidine whereas N-(amino)phenylmethylene-3-Cl-propionamide didnt solve. It was dried in vacuum over P2O5. Yield of clean product 94% from theoretical. MP: 98°-99°C. The solution of 9.2 g diethyl amine in 50 ml dry benzene was added dropwise to a suspension of above prepared N(amino)phenylmethylene-3-Cl-propionamide in dry benzene with stirring and cooling.
The mixture was warmed and stirred else 2 hours after adding. Then it was cooled, washed two times with water and dried over CaCl2. Then the solvent was removed. The residue was distilled in vacuum. Diethyl-[2-(3phenyl[1,2,4]oxadiasol-5)ethyl]amine (oxolamine) had BP: 127°C/0.4 mm. Yield 10.5 g.
Therapeutic Function
Antitussive, Antiinflammatory
Safety Profile
Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
![53919-74-7](/CAS/GIF/53919-74-7.gif)
![660-68-4](/CAS/GIF/660-68-4.gif)
![959-14-8](/CAS/GIF/959-14-8.gif)
Oxolamine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12459 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8828 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2255 | 58 |
Hebei Duling International Trade Co. LTD | +8617333973358 | sales01@hbduling.cn | China | 15438 | 58 |
PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35451 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 19947 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |