ChemicalBook >> CAS DataBase List >>PH11

PH11

PH11 structure

CAS No.: 1627843-95-1

Chemical Name:: PH11

Synonyms: PH11;Benzoic acid, 2-[[4-[(3,4,5-trimethoxyphenyl)amino]imidazo[1,2-a]-1,3,5-triazin-2-yl]amino]-, methyl ester

CBNumber:: CB54919875

Molecular Formula:: C22H22N6O5

Molecular Weight:: 450.45

MDL Number:

MOL File:: 1627843-95-1.mol

Last updated:2023-03-31 09:12:58

Request For Quotation

PH11 Properties

Density	1.37±0.1 g/cm3(Predicted)
pka	5.26±0.30(Predicted)

PH11 Chemical Properties,Uses,Production

Description

PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT pathways. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) emerges as one of the most-promising experimental cancer therapeutic drugs and is currently being tested in clinical trials. However, both intrinsic and acquired resistance of human cancer cells to TRAIL-induced apoptosis poses a huge problem in establishing clinically efficient TRAIL therapies.

PH11 Preparation Products And Raw materials

Raw materials

Preparation Products

PH11 Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	28118	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

PH11 Benzoic acid, 2-[[4-[(3,4,5-trimethoxyphenyl)amino]imidazo[1,2-a]-1,3,5-triazin-2-yl]amino]-, methyl ester 1627843-95-1