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TG003

TG003 structure

CAS No.: 300801-52-9

Chemical Name:: TG003

Synonyms: CS-955;CS-1704;(E/Z)-TG003;TG003/TG-003;TG003 USP/EP/BP;Cdc2-Like Kinase Inhibitor, TG003;1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone;2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)-;1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one;(1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one

CBNumber:: CB5505045

Molecular Formula:: C13H15NO2S

Molecular Weight:: 249.33

MDL Number:: MFCD00624584

MOL File:: 300801-52-9.mol

Last updated:2024-11-19 23:02:33

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TG003 Properties

Melting point	132-132.5 °C
Boiling point	386.0±42.0 °C(Predicted)
Density	1.237±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 33 mg/mL
form	solid
pka	-1.76±0.20(Predicted)
color	pale yellow
Sensitive	Light Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

NFPA 704

	0
2		0

TG003 price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T5575	TG003 ≥98% (HPLC)	300801-52-9	5mg	$196	2024-03-01	Buy
Sigma-Aldrich	T5575	TG003 ≥98% (HPLC)	300801-52-9	25mg	$778	2024-03-01	Buy
Alfa Aesar	J64690	Cdc2-Like Kinase Inhibitor, TG003	300801-52-9	5mg	$85.1	2023-06-20	Buy
Alfa Aesar	J64690	Cdc2-Like Kinase Inhibitor, TG003	300801-52-9	50mg	$551	2023-06-20	Buy
Cayman Chemical	10398	TG003 ≥95%	300801-52-9	1mg	$23	2024-03-01	Buy

Product number	Packaging	Price	Buy
T5575	5mg	$196	Buy
T5575	25mg	$778	Buy
J64690	5mg	$85.1	Buy
J64690	50mg	$551	Buy
10398	1mg	$23	Buy

TG003 Chemical Properties,Uses,Production

Description

Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC₅₀ values of 20 and 15 nM, respectively. TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC₅₀ = 200 nM and >10 μM, respectively). Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro. At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.

Uses

TG003 can be used as a potent CDC-2 kinase inhibitor, allowing for research into identification of signaling pathways and possible therapeutic treatments.

Uses

Cdc2-Like Kinase Inhibitor, TG003 is a benzothiazole agent that acts as a specific and ATP-competitive inhibitor of Clk family members. Reports show that TG003 modifies the regulation of alternative splicing modulated by phosphorylation of SR proteins in vitro, and rescues defects in the development of Xenopus caused by an overabundance of Clk activity.

Uses

TG003 has been used in PAC1 cell culture and in vitro kinase assays.

Biochem/physiol Actions

TG003, a CLK (cdc2-like kinase) family inhibitor is used as a drug for duchenne muscular dystrophy.

TG003 Preparation Products And Raw materials

Raw materials

Preparation Products

TG003 Suppliers

Global( 75)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55

View Lastest Price from TG003 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	(E/Z)-TG003 300801-52-9	US $41.00-81.00 / mg		99.04%	10g	TargetMol Chemicals Inc.

(E/Z)-TG003
300801-52-9
US $41.00-81.00 / mg
99.04%
TargetMol Chemicals Inc.

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Cdc2-Like Kinase Inhibitor, TG003 TG003/TG-003 2-Propanone,1-(3-ethyl-5-Methoxy-2(3H)-benzothiazolylidene)- (1Z)-1-(3-Ethyl-5-methoxy-1,3-benzothiazol-2-ylidene)propan-2-one 1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone (Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one CS-955 CS-1704 1-(3-Ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one TG003 USP/EP/BP (E/Z)-TG003 (E/Z) TG003,Cyclin dependent kinase,site,tumor,(E/Z)-TG003,Wilm's,(E/Z)-TG-003,splice,inhibit,mutation,Inhibitor,CDK,cancer,(E/Z)TG003,breast 300801-52-9 Inhibitors