ChemicalBook >> CAS DataBase List >>Endovion
Endovion
- CAS No.
- 265646-85-3
- Chemical Name:
- Endovion
- Synonyms
- NS3728;Endovion;NS3728 >=98% (HPLC);Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
- CBNumber:
- CB55419734
- Molecular Formula:
- C16H9BrF6N6O
- Molecular Weight:
- 495.18
- MDL Number:
- MFCD28147607
- MOL File:
- 265646-85-3.mol
Last updated:2024-11-19 20:33:22
| Density | 1.791±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| pka | 3.95±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | Water : < 0.1 mg/mL (insoluble) |
| FDA UNII | 943YH53W21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Endovion price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 6973 | NS3728 ≥98%(HPLC) | 265646-85-3 | 50 | $669 | 2021-12-16 | Buy |
| TRC | N926063 | NS3728 | 265646-85-3 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0026942 | Endovion 99.27% | 265646-85-3 | 25mg | $320 | 2021-12-16 | Buy |
| ChemScene | CS-0026942 | Endovion 99.27% | 265646-85-3 | 5mg | $90 | 2021-12-16 | Buy |
| ChemScene | CS-0026942 | Endovion 99.27% | 265646-85-3 | 50mg | $580 | 2021-12-16 | Buy |
Endovion Chemical Properties,Uses,Production
Biological Activity
Endovion (NS3728) is an anion channel inhibitor (eg chloride channel) and a specific VRAC/VSOAC blocker.
in vitro
Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, eg, expression of p21 Waf1/Cip1 , Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells.
Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines.
Western Blot Analysis
| Cell Line: | Wild -type, resistant, and transiently transfected A2780 cells. |
| Concentration: | 10-100 μM. < /td> |
| Incubation Time: | 18 or 4.5 h. |
| Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells. Resulted i n an increased LRRC8A protein expression. Significantly reduced p53 and p21Waf1/Cip1 protein level in A2780WT cells. |
Cell Proliferation Assay
| Cell Line: | Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines. |
| Concentration: | 10 μM. |
| Incubation Time: | 24 h. |
| Result: | Resulted in the most pronounced inhibition in all cell lines with 77 ± 26 % in Capan-1, 67 ± 9 % in AsPC-1, and 54 ± 8 % in BxPC-3 cells at +67 mV. |
target
Chloride channel, VRAC/VSOAC.
ANO1.
storage
Store at -20°C
Endovion Preparation Products And Raw materials
Raw materials
Preparation Products
Endovion Suppliers
Global( 33)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13464 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 3576 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4512 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2987 | 58 |
Endovion
NS3728
Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
NS3728 >=98% (HPLC)
1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea
Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728
265646-85-3
CHBrFNO
C16H9BrF6N6O