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ChemicalBook >> CAS DataBase List >>4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Structure
4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol structure
CAS No.
1202764-53-1
Chemical Name:
4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol
Synonyms
B022;B022,B-022;4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol;4-(1-(2-Amino-5-chloropyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol;2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl-
CBNumber:
CB55582861
Molecular Formula:
C19H16ClN5OS
Molecular Weight:
397.88
MDL Number:
MFCD32645350
MOL File:
1202764-53-1.mol
Last updated:2024-11-06 15:28:16
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4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Properties

Boiling point 644.4±65.0 °C(Predicted)
Density 1.53±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 250 mg/mL (628.33 mM)
form Solid
pka 10.71±0.29(Predicted)
color Light yellow to yellow

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0078192 B022 98.10% 1202764-53-1 5mg $205 2021-12-16 Buy
ChemScene CS-0078192 B022 98.10% 1202764-53-1 10mg $350 2021-12-16 Buy
ChemScene CS-0078192 B022 98.10% 1202764-53-1 50mg $1250 2021-12-16 Buy
ChemScene CS-0078192 B022 98.10% 1202764-53-1 100mg $2200 2021-12-16 Buy
Product number Packaging Price Buy
CS-0078192 5mg $205 Buy
CS-0078192 10mg $350 Buy
CS-0078192 50mg $1250 Buy
CS-0078192 100mg $2200 Buy

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Chemical Properties,Uses,Production

Biological Activity

B022 is a potent and selective NF-κB-inducible kinase (NIK) inhibitor with Ki of 4.2 nM. B022 protects the liver from inflammation, oxidative stress and damage caused by toxins.

in vitro

B022 (0-5 μM; 12 hours; Hepa1 cells) treatment suppresses NIK-induced p52 formation in a dose-dependent manner.
B022 (0-5 μM; 12 hours; Hepa1 cells) treatment for 8 h completely blocks NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.

Western Blot Analysis

Cell Line: Hepa1 cells
Concentration: 0 μM, 0.5 μM, 5 μM
Incubation Time: 12 hours
Result: Suppressed NIK-induced p52 formation in a dose-dependent manner. td>

RT-PCR

Cell Line: Hepa1 cells
Concentration: 0 μM, 0.5 μM, 5 μM
Incubation Time: 12 hours
Result: Dose-dependently blocked NIK-induced expression of chemokines, cytokines, and iNOS in these cells. Completely blocked NIK-induced expression of TNF-a, IL-6, iNOS, CCL2, and CXCL5.
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in vivo

B022 (30 mg/kg; intravenous injection; twice a day; for 10 days; STOP-NIK male mice) treatment inhibits NIK-triggered liver inflammation and injury in STOP-NIK mice infected with cre adenoviruses. < /p>

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Animal Model: STOP-NIK male mice (8 weeks) infected with Ad-cre
Dosage: 30 mg/kg
Administration: Intravenous injection; twice a day; for 10 days
Result: Completely prevents the lethal effect of abnormally high levels of hepatic NIK in mice. Inhibited the majority of the deteriorating effects of aberrant activation of hepatic NIK.

target

Ki: 4.2 nM (NF-κB-inducing kinase (NIK))

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol Suppliers

Global( 29)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32072 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38466 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3466 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4456 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8012 62
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29785 68
Heze Development Zone chuangli Chemical Co., Ltd. +86-530-529 6766，+86-15666160102 15666160102 info@chuangli-chem.com China 890 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Aladdin Scientific 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai EFE Biological Technology Co., Ltd. 58
ShangHai Biochempartner Co.,Ltd 62
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Heze Development Zone chuangli Chemical Co., Ltd. 55

View Lastest Price from 4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
B022 pictures 2024-11-06 B022
1202764-53-1
 US $68.00-247.00 / mg 99.74% 10g TargetMol Chemicals Inc.
B022 pictures 2024-11-06 B022
1202764-53-1
 US $68.00-247.00 / mg 99.74% 10g TargetMol Chemicals Inc.
  • B022 pictures
  • B022
    1202764-53-1
  • US $68.00-247.00 / mg
  • 99.74%
  • TargetMol Chemicals Inc.
  • B022 pictures
  • B022
    1202764-53-1
  • US $68.00-247.00 / mg
  • 99.74%
  • TargetMol Chemicals Inc.
4-(1-(2-amino-5-chloropyrimidin-4-yl)-2-(thiaol-2-yl)but-30-yn-2-ol B022 2-Thiazolemethanol, α-[2-[1-(2-amino-5-chloro-4-pyrimidinyl)-2,3-dihydro-1H-indol-6-yl]ethynyl]-α-methyl- B022,B-022 4-(1-(2-Amino-5-chloropyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol 1202764-53-1