C-021 dihydrochloride
- CAS No.
- 1784252-84-1
- Chemical Name:
- C-021 dihydrochloride
- Synonyms
- 2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine dihydrochloride;2-([1,4'-Bipiperidin]-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine dihydrochloride;Inhibitor,C 021 dihydrochloride,CCL22,CCR4,C021,C021 dihydrochloride,CCR,C 021,CC chemokine receptor,inhibit,C-021,GTPγS,chemotaxis
- CBNumber:
- CB55867403
- Molecular Formula:
- C27H42ClN5O2
- Molecular Weight:
- 504.12
- MDL Number:
- MOL File:
- 1784252-84-1.mol
C-021 dihydrochloride price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21885 | CCR4 Antagonist (hydrochloride) ≥98% | 1784252-84-1 | 1 mg | $59 | 2024-03-01 | Buy |
Cayman Chemical | 21885 | CCR4 Antagonist (hydrochloride) ≥98% | 1784252-84-1 | 5 mg | $184 | 2024-03-01 | Buy |
ChemScene | CS-0087635 | C-021(dihydrochloride) >99.0% | 1784252-84-1 | 5mg | $525 | 2021-12-16 | Buy |
ChemScene | CS-0087635 | C-021(dihydrochloride) >99.0% | 1784252-84-1 | 10mg | $895 | 2021-12-16 | Buy |
ChemScene | CS-0087635 | C-021(dihydrochloride) >99.0% | 1784252-84-1 | 1mg | $175 | 2021-12-16 | Buy |
C-021 dihydrochloride Chemical Properties,Uses,Production
Description
Chemokine (C-C motif) receptor 4 (CCR4) antagonist is an antagonist of CCR4.1 It inhibits activation of CCR4 by chemokine (C-C motif) ligand 22 (CCL22) in a [35S]GTPγS assay and also inhibits chemotaxis in human and mouse CCR4-expressing B300-19 cells (IC50s = 18, 140, and 39 nM, respectively). CCR4 antagonist inhibits microglial activation in the cortex in a mouse model of hepatic encephalopathy induced by the neurotoxin azoxymethane when administered at a dose of 1 mg/kg per day.2 It reduces azoxymethane-induced increases in Il6 and Il1b expression in mouse cortex. CCR4 antagonist reduces mechanical and thermal sensitivity in a mouse model of type I diabetes induced by streptozotocin when administered intrathecally at doses ranging from 10 to 30 μg/animal.3
storage
Desiccate at RT
References
1. Yokoyama, K., Ishikawa, N., Igarashi, S., et al. Discovery of potent CCR4 antagonists: Synthesis and structure-
2. McMillin, M., Frampton, G., Thompson, M., et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline J. Neuroinflammation 11,121(2014).
3. Bogacka, J., Ciapa?a, K., Pawlik, K., et al. Blockade of CCR4 diminishes hypersensitivity and enhances opioid analgesia -
C-021 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
C-021 dihydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3717 | 55 |
Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2853979810@qq.com | China | 10015 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb5@aikonchem.com | China | 10529 | 58 |