ChemicalBook >> CAS DataBase List >>1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-

1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-

1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- structure

CAS No.: 1093412-18-0

Chemical Name:: 1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-

Synonyms: FFPM;Roflupram;Roflupram >=98% (HPLC);1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl-

CBNumber:: CB55875992

Molecular Formula:: C16H20F2O4

Molecular Weight:: 314.32

MDL Number:: MFCD31697733

MOL File:: 1093412-18-0.mol

Last updated:2024-07-02 08:55:11

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1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Properties

storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (318.15 mM; Need ultrasonic)
form	Liquid
color	Colorless to light yellow

1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML2106	Roflupram ≥98% (HPLC)	1093412-18-0	5MG	$105	2024-03-01	Buy
Sigma-Aldrich	SML2106	Roflupram ≥98% (HPLC)	1093412-18-0	25MG	$424	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML2106	5MG	$105	Buy
SML2106	25MG	$424	Buy

1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Chemical Properties,Uses,Production

Biological Activity

Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC50 of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors[1][2].

References

[1]. Li D, et, al. Roflupram, a novel phosphodiesterase 4 inhibitor, inhibits lipopolysaccharide-induced neuroinflammatory responses through activation of the AMPK/Sirt1 pathway. Int Immunopharmacol. 2021 Jan;90:107176. [2]. You T, et, al. Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells. ACS Chem Neurosci. 2017 Nov 15;8(11):2381-2392.

1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Block Chemical Technology (Shanghai) Co., Ltd.	021-20432219 13918097649	li_jinfei@acblock-lab.com	China	9913	58
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5014	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9155	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Block Chemical Technology (Shanghai) Co., Ltd.	58
Energy Chemical	58
TargetMol Chemicals Inc.	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58
RD International Technology Co., Limited	58

FFPM Roflupram >=98% (HPLC) 1-Butanone, 1-[4-(difluoromethoxy)-3-[(tetrahydro-3-furanyl)oxy]phenyl]-3-methyl- Roflupram 1093412-18-0 C16H20F2O4