DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P)
- CAS No.
- 24738-51-0
- Chemical Name:
- DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P)
- Synonyms
- Dienamide A2;DODECA-2(E)-DIENOIC ACID ISOBUTYLAMIDE;(2E,4E)-N-isobutyldodeca-2,4-dienamide;DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P);2,4-Dodecadienamide, N-(2-methylpropyl)-, (2E,4E)-
- CBNumber:
- CB5655029
- Molecular Formula:
- C16H29NO
- Molecular Weight:
- 251.41
- MDL Number:
- MOL File:
- 24738-51-0.mol
| storage temp. | -20°C |
|---|---|
| solubility | Soluble in DMSO (up to 25 mg/ml) on in Ethanol (up to 25 mg/ml) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchsae as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| LogP | 4.962 (est) |
| FDA UNII | 5F4WO3BVS9 |
DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P) price More Price(1)
DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P) Chemical Properties,Uses,Production
Description
Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human monocytes/macrophages via the CB2 receptor.1?Dienamide A2 binds to cannabinoid receptors with greater affinity than endogenous cannabinoids (Ki= ~60 and >1500 nM for CB2 and CB1 respectively)2. It elevates intracellular Ca2+ levels in CB2-positive? but not in CB2-negative cells and this effect was blocked by SR144528.2??It significantly inhibits LPS-induced TNFα and IL-1β expression in a CB2-independent manner.2
Uses
Kalecide is a natural pesticide of Echinacea angustifolia, Echinacea atrorubens and Piper sarmentosum.
Definition
ChEBI: (2E,4E)-N-isobutyl-2,4-dodecadienamide is a fatty amide. It has a role as a metabolite.
References
1) Gertsch?et al. (2004), Echinacea alkylamides modulate TNF-alpha gene expression via cannabinoid receptor CB2 and multiple signal transduction pathways; FEBS Lett., 577?563 2) Raduner?et al. (2006), Alkylamides from Echinacea are a new class of cannabinomimetics.? Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects; J. Biol. Chem., 281?14192
DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P) Preparation Products And Raw materials
Raw materials
Preparation Products
DODECA-2(E),4(E)-DIENOIC ACID ISOBUTYLAMIDE(P) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | rose.shi@synzest.com | China | 6210 | 58 |
| Supplier | Advantage |
|---|---|
| Nanjing Shizhou Biology Technology Co.,Ltd | 58 |