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Physalaemin

Physalaemin structure

CAS No.: 2507-24-6

Chemical Name:: Physalaemin

Synonyms: FI 6422;Physalemin;PHYSALAEMIN;Physalaemine;PHYSALAEMIN ACOH 3H2O;Physalemin(7CI,8CI,9CI);Physalaemin, ≥97% (HPLC);GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2

CBNumber:: CB5674482

Molecular Formula:: C58H84N14O16S

Molecular Weight:: 1265.44

MDL Number:: MFCD00076375

MOL File:: 2507-24-6.mol

Last updated:2023-07-17 20:29:20

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Physalaemin Properties

storage temp.	−20°C
solubility	Soluble in DMSO
InChIKey	SHSUJLMLURFKID-PYQGFWJGNA-N
FDA UNII	H0T4KV6B9J

SAFETY

Risk and Safety Statements

WGK Germany	3

Physalaemin price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	P4079-40	Physalaemin	2507-24-6	1mg	$531	2021-12-16	Buy
American Custom Chemicals Corporation	PEP0002856	PHYSALAEMIN 95.00%	2507-24-6	1MG	$571.21	2021-12-16	Buy
American Custom Chemicals Corporation	PEP0002856	PHYSALAEMIN 95.00%	2507-24-6	5MG	$679.72	2021-12-16	Buy

Product number	Packaging	Price	Buy
P4079-40	1mg	$531	Buy
PEP0002856	1MG	$571.21	Buy
PEP0002856	5MG	$679.72	Buy

Physalaemin Chemical Properties,Uses,Production

Description

Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.

Uses

Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?

Biological Activity

Physalaemin is a non-mammalian tachykinin that selectively binds with high affinity to the neurokinin-1 (NK1) receptor.

in vitro

Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized. Physalaemin is a bradykinin potentiating peptide (BPP-5a).

target

Neurokinin-1 (NK1) receptor

References

[1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457

Physalaemin Preparation Products And Raw materials

Raw materials

Preparation Products

Physalaemin Suppliers

Global( 71)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10311	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Hangzhou Go Top Peptide Biotech	0571-88211921	sales1@gotopbio.com	CHINA	2609	58
Chengdu Youngshe Chemical Co., Ltd.	+8618108235634	Cecilia@youngshechem.com	China	2345	58
Nanjing TGpeptide	+86-13347807150 +86-13347807150	support@tgpeptide.com	China	3279	58
Changsha MOL Changes Biotechnology Co., Ltd.	+8619375158599	info@molchanges.com	China	5223	58
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42958	64

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Cellmano Biotech Limited	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hangzhou Go Top Peptide Biotech	58
Chengdu Youngshe Chemical Co., Ltd.	58
Nanjing TGpeptide	58
Changsha MOL Changes Biotechnology Co., Ltd.	58
Shanghai Hanhong Scientific Co.,Ltd.	64

View Lastest Price from Physalaemin manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-03-06	PHYSALAEMIN 2507-24-6	US $1.00 / g	1g	≥98%	g/kg/Ton	Career Henan Chemical Co

PHYSALAEMIN
2507-24-6
US $1.00 / g
≥98%
Career Henan Chemical Co

2507-24-6(Physalaemin)Related Search:

[L-Lys5,L-Thr6]physalaemin physalaemin, Lys(5)-Thr(6)- physalaemin C-terminal heptapeptide [[(S,S)PRO-LEU(SPIRO-GAMMA-LACTAM)]9,10, TRP11]PHYSALAEMIN (1-11) GLY-LEU-MET-NH2

4-PYRROLIDIN-1-YL-BUTAN-1-OL AC-PHE-TYR-NH2 SUBSTANCE P (7-11) Physalaemin N,N-DIMETHYLSUCCINAMIC ACID

4-OXO-4-PYRROLIDIN-1-YL-BUTYRIC ACID AC-MET-NH2 pyrrolidine-1-butyric acid 4-(2-CARBAMOYL-PYRROLIDIN-1-YL)-4-OXO-BUTYRIC ACID

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FI 6422 Physalemin(7CI,8CI,9CI) PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 PHYSALAEMIN PHYSALAEMIN ACOH 3H2O PYROGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET NH2 PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 ACOH 3H2O GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 5-Oxo-L-Pro-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2 L-pGlu-L-Ala-L-Asp-L-Pro-L-Asn-L-Lys-L-Phe-L-Tyr-Gly-L-Leu-L-Met-NH2 Physalaemine Physalemin Physalaemin, ≥97% (HPLC) L-Methioninamide, 5-oxo-L-prolyl-L-alanyl-L-α-aspartyl-L-prolyl-L-asparaginyl-L-lysyl-L-phenylalanyl-L-tyrosylglycyl-L-leucyl- 2507-24-6 C58H84N14O16S1 C58H84N14O16S Biochemicals and Reagents Amino Acids and Peptides BioChemical Peptides Tachykinins Peptide