피살라민

피살라민
피살라민 구조식 이미지
카스 번호:
2507-24-6
한글명:
피살라민
동의어(한글):
피살라민
상품명:
Physalaemin
동의어(영문):
FI 6422;Physalemin;PHYSALAEMIN;Physalaemine;PHYSALAEMIN ACOH 3H2O;Physalemin(7CI,8CI,9CI);Physalaemin, ≥97% (HPLC);GLP-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2
CBNumber:
CB5674482
분자식:
C58H84N14O16S
포뮬러 무게:
1265.44
MOL 파일:
2507-24-6.mol

피살라민 속성

저장 조건
−20°C
용해도
DMSO에 용해됨
InChIKey
SHSUJLMLURFKID-PYQGFWJGNA-N

안전

WGK 독일 3

피살라민 C화학적 특성, 용도, 생산

개요

Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects.

용도

Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease.?

참고 문헌

[1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457

피살라민 준비 용품 및 원자재

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