4-TRIMETHYLSILYL-3-BUTYN-2-OL
- CAS No.
- 6999-19-5
- Chemical Name:
- 4-TRIMETHYLSILYL-3-BUTYN-2-OL
- Synonyms
- DK369;TIMTEC-BB SBB009027;4-TRIMETHYLSILYL-3-BUTYN-2-OL;4-(Trimethysilyl)-3-butyn-2-ol;1-TRIMETHYLSILYLBUT-1-YNE-3-OL;4-Trimethylsilyl-3-butynol, t;4-(triMethylsilyl)but-3-yn-2-ol;3-Butyn-2-ol, 4-(trimethylsilyl)-;(+/-) 4-TRIMETHYLSILYL-3-BUTYN-2-OL;4-TRIMETHYLSILYL-3-BUTYN-2-OL (+/-)
- CBNumber:
- CB5676325
- Molecular Formula:
- C7H14OSi
- Molecular Weight:
- 142.27
- MDL Number:
- MFCD00190213
- MOL File:
- 6999-19-5.mol
- MSDS File:
- SDS
Boiling point | 76 °C |
---|---|
Density | 0.847 g/mL at 25 °C |
refractive index |
n |
Flash point | 143 °F |
storage temp. | 2-8°C |
solubility | highly soluble in all standard organic solvents (hexanes, toluene, CH2Cl2, EtOAc, alcohols, ethers). Partially soluble in water. |
pka | 13.78±0.20(Predicted) |
form | clear liquid |
color | Colorless to Light orange to Yellow |
Specific Gravity | 0.846 |
Hydrolytic Sensitivity | 4: no reaction with water under neutral conditions |
BRN | 1923632 |
CAS DataBase Reference | 6999-19-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26 | |||||||||
RIDADR | 1993 | |||||||||
WGK Germany | 3 | |||||||||
TSCA | No | |||||||||
HazardClass | 3 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29319090 | |||||||||
NFPA 704 |
|
4-TRIMETHYLSILYL-3-BUTYN-2-OL price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 666955 | 4-(Trimethylsilyl)-3-butyn-2-ol 97% | 6999-19-5 | 5g | $45.3 | 2023-06-20 | Buy |
Sigma-Aldrich | 666955 | 4-(Trimethylsilyl)-3-butyn-2-ol 97% | 6999-19-5 | 25g | $225 | 2023-01-07 | Buy |
TCI Chemical | T1926 | 4-Trimethylsilyl-3-butyn-2-ol >97.0%(GC) | 6999-19-5 | 5g | $66 | 2024-03-01 | Buy |
Alfa Aesar | L14815 | 4-Trimethylsilyl-3-butyn-2-ol, 97% | 6999-19-5 | 5g | $62.65 | 2024-03-01 | Buy |
Alfa Aesar | L14815 | 4-Trimethylsilyl-3-butyn-2-ol, 97% | 6999-19-5 | 25g | $207.65 | 2024-03-01 | Buy |
4-TRIMETHYLSILYL-3-BUTYN-2-OL Chemical Properties,Uses,Production
Chemical Properties
Colorless liquid
Physical properties
bp 83–85°C (13 mmHg).
Uses
More recently, Mulzer has reported use of the corresponding
allenylsilane derived from 4-TMS-3-butyn-2-ol for use in the synthesis
of the C13–C18 fragment of branimycin (eq 2).
Preparation
racemic 4-trimethylsilyl-3-butyn-2-ol can
be prepared by deprotonation with strong bases (BuLi, LDA,
Grignards reagents) of trimethylsilylacetylene followed
by addition to acetaldehyde.Deprotonation of 3-butyn-2-
ol followed by quenching with excess trimethylsilyl chloride
followed by concomitant hydrolysis of the trimethylsilyl ether
is generally the most straightforward route.Enzymatic reduction
of 4-TMS-3-butyn-2-one has also been used to prepare the
reagent using alcohol dehydrogenase.
Preparation of nonracemic 4-TMS-3-butyn-2-ol has been
accomplished by asymmetric addition of dimethylzinc to
acetaldehyde promoted by TADDOL or addition of a
trimethylsilylvinylsulfoxide to acetaldehyde followed by thermal
elimination of the sulfoxide.Asymmetric reduction of 4-
TMS-3-butyn-2-one using stoichiometric reducing reagents,
catalytic transfer hydrodrogenation,and enzymatic reduction
with isolated protein or whole cells afford the 4-TMS-3-butyn-
2-ol with varying degrees of enantioenrichment.Enzymatic resolution by esterification of the racemic alcohol is the method
of choice for the large-scale preparation.
4-TRIMETHYLSILYL-3-BUTYN-2-OL Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei Co-Formula Material Tech Co., Ltd. | +86-27-84459282 | sales@cfmats.com | CHINA | 882 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
Bio Connect Life Sciences | info@bio-connect.nl | United States | 261 | 58 |
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