3-IODO-L-TYROSINE
- CAS No.
- 70-78-0
- Chemical Name:
- 3-IODO-L-TYROSINE
- Synonyms
- H-Tyr;NSC210787;3-I-L-Tyr-OH;H-3-I-TYR-OH;Iodotyrosine;H-TYR(M-I)-OH;H-TYR(3-I)-OH;3-Iodo-Tyr-OH;3-IODO-TYROSINE;H-L-TYR(3-I)-OH
- CBNumber:
- CB5721061
- Molecular Formula:
- C9H10INO3
- Molecular Weight:
- 307.09
- MDL Number:
- MFCD00002608
- MOL File:
- 70-78-0.mol
- MSDS File:
- SDS
Melting point | 210 °C (dec.)(lit.) |
---|---|
Density | 1.7280 (estimate) |
storage temp. | -20°C |
solubility | dilute aqueous acid: soluble |
form | Solid |
Boiling point | 391.0±42.0 °C(Predicted) |
pka | 2.21±0.20(Predicted) |
color | White to off-white |
Sensitive | Light Sensitive |
Merck | 14,5047 |
BRN | 2941266 |
Stability | Hygroscopic |
InChIKey | UQTZMGFTRHFAAM-ZETCQYMHSA-N |
CAS DataBase Reference | 70-78-0(CAS DataBase Reference) |
FDA UNII | FRQ98U4U27 |
EPA Substance Registry System | L-Tyrosine, 3-iodo- (70-78-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS05 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H314 | |||||||||
Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
Safety Statements | 24/25 | |||||||||
WGK Germany | 3 | |||||||||
F | 8-10-23 | |||||||||
HS Code | 29225090 | |||||||||
NFPA 704 |
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3-IODO-L-TYROSINE price More Price(48)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | I8250 | 3-Iodo-L-tyrosine | 70-78-0 | 1g | $68.4 | 2024-03-01 | Buy |
Sigma-Aldrich | I8250 | 3-Iodo-L-tyrosine | 70-78-0 | 5g | $249 | 2024-03-01 | Buy |
TCI Chemical | I0075 | 3-Iodo-L-tyrosine >98.0%(T) | 70-78-0 | 1g | $83 | 2024-03-01 | Buy |
TCI Chemical | I0075 | 3-Iodo-L-tyrosine >98.0%(T) | 70-78-0 | 5g | $329 | 2024-03-01 | Buy |
Alfa Aesar | H63789 | 3-Iodo-L-tyrosine, 98% | 70-78-0 | 1g | $33.65 | 2024-03-01 | Buy |
3-IODO-L-TYROSINE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.
Uses
A novel flavoprotein responsible for iodide salvage in thyroid glands. A tyrosine hydroxylase inhibitor.
Uses
3-iodo-l-tyrosine is used in the inhibition of tyrosine hydroxylase. 3-iodo-L-tyrosine is used in the rapid induction of prolactin secretion.
Definition
ChEBI: The monoiodotyrosine that is L-tyrosine carrying an iodo-substituent at position C-3 of the benzyl group.
General Description
Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).
Biochem/physiol Actions
3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.
Purification Methods
Likely impurities are tyrosine, diiodotyrosine and iodide. Crystallise it by dissolving it in concentrated ammonia (~200mg in ~20mL), evaporate to ~5mL and NH4Cl is added to pH4.5—5.0. After a few hours at 0o, the amino acid crystallises in needles. It is filtered off, washed with a little ice-cold H2O and dried in a vacuum. Alternatively dissolve it in dilute ammonia at room temperature, then add dilute acetic acid to pH 6. Store it at 0o. Recrystallisation of ~250mg from H2O (~5mL) removes any diiodotyrosine. It is an inhibitor of tyrosine hydroxylase with a Ki of ~500nM. [Harrington & Rivers Biochem J 38 320 1944, Rivers Chem & Ind (London) 21 1956, Beilstein 14 III 1562, 14 IV 1562.]
3-IODO-L-TYROSINE Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Suzhou Ryan Pharmachem Technology Co.,Ltd. | +86-512-68780025 +8618962125825 | sales@ryanchem.com | China | 137 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29892 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
GL Biochem(Binhai) Ltd. | +86-021-61263370 +8615301650015 | wuqiuyan@glschina.com | China | 2975 | 58 |
View Lastest Price from 3-IODO-L-TYROSINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2023-05-12 | 3-iodo-L -tyrosine
70-78-0
|
US $0.00-0.00 / kg | 5kg | 98% | kg grade | Suzhou Ryan Pharmachem Technology Co.,Ltd. | |
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2022-02-19 | 3-Iodo-l-tyrosine
70-78-0
|
US $0.00 / KG | 1KG | 98.5% | 100 tons | Honest Joy Holdings Limited
|
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2019-07-10 | 3-IODO-L-TYROSINE
70-78-0
|
US $1.00 / ASSAYS | 1ASSAYS | 98% | 1kg,2kg,100kg | Career Henan Chemical Co |
-
- 3-iodo-L -tyrosine
70-78-0
- US $0.00-0.00 / kg
- 98%
- Suzhou Ryan Pharmachem Technology Co.,Ltd.
-
- 3-Iodo-l-tyrosine
70-78-0
- US $0.00 / KG
- 98.5%
- Honest Joy Holdings Limited
-
- 3-IODO-L-TYROSINE
70-78-0
- US $1.00 / ASSAYS
- 98%
- Career Henan Chemical Co
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