ANTI-GI ALPHA-3 (GIALPHA3)
- CAS No.
- Chemical Name:
- ANTI-GI ALPHA-3 (GIALPHA3)
- Synonyms
- ANTI-GI ALPHA-3 (GIALPHA3);ANTI-GI-ALPHA-3-SUBUNIT (AB-5), MAMMALIAN;Anti-Gα i3 antibody produced in rabbit;ANTI-GI-ALPHA-3-SUBUNIT, C-TERMINAL (345-354);ANTI-GIALPHA-3-SUBUNIT, C-TERMINAL (345-354) (RABBIT);ANTI-GI-ALPHA,-3 SUBUNIT, C-TERMINUSSEQUENCE [345-354];ANTI-GI-ALPHA-3-SUBUNIT, C-TERMINAL (345-354) RABBIT PAB
- CBNumber:
- CB5763269
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00239679
- MOL File:
- Mol file
ANTI-GI ALPHA-3 (GIALPHA3) Chemical Properties,Uses,Production
Uses
Anti-Gα i3 antibody produced in rabbit is suitable for immunoprecipitation at a working antibody amount of 4μL using solubilized mouse brain membrane lysates and immunoblotting at a working dilution of 1:2000 using solubilized mouse and rat brain membrane lysates, and mouse 3T3 cell lysates.
General Description
G-proteins are membrane associated heterotrimeric proteins that are comprised of α-, β-, and λ-subunits. These proteins play a key role in signal transduction pathways that regulate cell′s response to several hormones, neuromodulators and ligands.
Biochem/physiol Actions
Gi α 3 is a G-protein subunit that is involved in many signal transduction pathways including the mediation of EGF-induced PLC-γ activation and Ca+2 mobilization in hepatocytes. The α-subunit contains a guanine-binding domain that is in its inactive state when it is occupied by GDP. Upon activation, GDP is replaced with GTP, causing the dissociation of the α-subunit from the βλ-subunit complex. This enables the Gα-GTP complex to bind to and regulate specific signaling pathways. GTP is then hydrolyzed, allowing for re-association of the α-subunit with the βλ-subunit complex.
ANTI-GI ALPHA-3 (GIALPHA3) Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-GI ALPHA-3 (GIALPHA3) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6773 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6896 | 91 | |
| American Qualex | -- | info@americanqualex.com | United States | 669 | 59 |
| Nacalai Tesque, Inc. | -- | info-tech@nacalai.co.jp | Japan | 6046 | 75 |
| EMD Biosciences, Inc. | -- | technical@calbiochem.com | United States | 6529 | 66 |
| VWR International | -- | solutions@vwr.com | United Kingdom | 6548 | 82 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |
| American Qualex | 59 |
| Nacalai Tesque, Inc. | 75 |
| EMD Biosciences, Inc. | 66 |
| VWR International | 82 |