3,4-DIHYDROQUINOLIN-2(1H)-ONE
- CAS No.
- 553-03-7
- Chemical Name:
- 3,4-DIHYDROQUINOLIN-2(1H)-ONE
- Synonyms
- 3,4-DIHYDRO-1H-QUINOLIN-2-ONE;HYDROCARBOSTYRIL;3,4-DIHYDRO-2(1H)-QUINOLINONE;inone;DIHYDROCARBOSTYRIL;dihydro-α-quinolone;3,4-Dihydrocarbostyril;3,4-Dihydro-2-quinolone;3,4-Dihydro-2(1H)-quinoL;3,4-Dihydro-2-quinolinone
- CBNumber:
- CB5772351
- Molecular Formula:
- C9H9NO
- Molecular Weight:
- 147.17
- MDL Number:
- MFCD00016722
- MOL File:
- 553-03-7.mol
- MSDS File:
- SDS
Melting point | 165-167 °C (lit.) |
---|---|
Boiling point | 267.28°C (rough estimate) |
Density | 1.1135 (rough estimate) |
refractive index | 1.5200 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml |
form | Crystalline Powder |
pka | 14.76±0.20(Predicted) |
color | Off-white |
Water Solubility | Slightly soluble in water. |
Sensitive | Light Sensitive |
Merck | 13,4800 |
CAS DataBase Reference | 553-03-7(CAS DataBase Reference) |
FDA UNII | 2CKG6TX32F |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS06 |
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Signal word | Warning | |||||||||
Hazard statements | H301-H302-H315-H317-H319-H335 | |||||||||
Precautionary statements | P280a-P301+P310a-P405-P501a-P261-P280-P305+P351+P338 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-36/37/38-43 | |||||||||
Safety Statements | 26-36/37 | |||||||||
RIDADR | 2811 | |||||||||
WGK Germany | 2 | |||||||||
Hazard Note | Irritant | |||||||||
HazardClass | 6.1(b) | |||||||||
PackingGroup | III | |||||||||
HS Code | 29337900 | |||||||||
NFPA 704 |
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3,4-DIHYDROQUINOLIN-2(1H)-ONE price More Price(41)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 415936 | 3,4-Dihydro-2(1H)-quinolinone 98% | 553-03-7 | 10g | $171 | 2023-06-20 | Buy |
Sigma-Aldrich | 415936 | 3,4-Dihydro-2(1H)-quinolinone 98% | 553-03-7 | 1g | $39.4 | 2023-01-07 | Buy |
Alfa Aesar | H36638 | 3,4-Dihydro-2-(1H)-quinolinone, 98% | 553-03-7 | 1g | $42.65 | 2024-03-01 | Buy |
Alfa Aesar | H36638 | 3,4-Dihydro-2-(1H)-quinolinone, 98% | 553-03-7 | 5g | $128.65 | 2024-03-01 | Buy |
Alfa Aesar | H36638 | 3,4-Dihydro-2-(1H)-quinolinone 98% | 553-03-7 | 25g | $440 | 2021-12-16 | Buy |
3,4-DIHYDROQUINOLIN-2(1H)-ONE Chemical Properties,Uses,Production
Chemical Properties
Off-white crystalline powder
Uses
3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments.
Uses
3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.
Definition
ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines.
Synthesis Reference(s)
Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
Tetrahedron Letters, 36, p. 125, 1995 DOI: 10.1016/0040-4039(94)02191-D
General Description
Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase
3,4-DIHYDROQUINOLIN-2(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10259 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29826 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 | admin@zhanyaobio.com | China | 2136 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 26466 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
View Lastest Price from 3,4-DIHYDROQUINOLIN-2(1H)-ONE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-03-04 | 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | ||
2021-10-15 | 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
|
US $10.00 / KG | 1KG | 99% | 20 tons | Hebei Zhanyao Biotechnology Co. Ltd | ||
2020-02-14 | 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
|
US $1.00 / KG | 1KG | 99% | 200kgs | Career Henan Chemical Co |
- 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
- 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
- US $10.00 / KG
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
- 1,2,3,4-Tetrahydroquinolin-2-one
553-03-7
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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