CALCINEURIN

CALCINEURIN structure

CAS No.: 90371-51-0

Chemical Name:: CALCINEURIN

Synonyms: CAN;PP2B;PPASE-2B;CALCINEURIN;CALCINEURIN/PP2B;CALCINEURIN, HUMAN;PROTEIN PHOSPHATASE 2B;Calcineurin bovine brain;MODULATOR BINDING PROTEIN;CALMODULIN BINDING PROTEIN

CBNumber:: CB5781726

Molecular Formula:

Molecular Weight:: 0

MDL Number:: MFCD00130697

MOL File:: Mol file

Last updated:2023-04-23 13:52:06

Request For Quotation

CALCINEURIN Properties

storage temp.	−20°C
solubility	H₂O: soluble
form	lyophilized powder

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

CALCINEURIN price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C1907	Calcineurin from bovine brain lyophilizedpowder,≥2,500?units/mgprotein	90371-51-0	100units	$740	2024-03-01	Buy
Usbiological	151626	Calcineurin	90371-51-0	200ul	$436	2021-12-16	Buy
Usbiological	405761	Calcineurin	90371-51-0	1Kit	$479	2021-12-16	Buy

Product number	Packaging	Price	Buy
C1907	100units	$740	Buy
151626	200ul	$436	Buy
405761	1Kit	$479	Buy

CALCINEURIN Chemical Properties,Uses,Production

Uses

Calcineurin from bovine brain has been used:

as a positive control in western blot analysis of oocytes and cumulus cells proteome
as a positive control in calmodulin (CaM)-agarose binding assay
to test its phosphatase activity in the presence of okadaic acid

General Description

Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain.

Biochem/physiol Actions

Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells.

CALCINEURIN Preparation Products And Raw materials

Raw materials

Preparation Products

CALCINEURIN Suppliers

Global( 16)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80

Supplier	Advantage
Sigma-Aldrich	80

90371-51-0(CALCINEURIN)Related Search:

TERT-BUTYL ISOCYANIDE Ethyl isocyanoacetate COBALT(II) ACETYLACETONATE METHYL ISOCYANOACETATE Tris(2,4-pentanedionato)chroMiuM(III)

Tosylmethyl isocyanide 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE PHENYLSELENOL Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)

Cupric acetylacetonate Benzyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE SALCOMINE N-BUTYLISOCYANIDE

Ferric acetylacetonate TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) CALCINEURIN,CALCINEURIN, HUMAN,CALCINEURIN/PP2B

1of4

CALCINEURIN FROM BOVINE BRAIN, >10 U/MG calcium/calmodulin-activated protein phosphatase MODULATOR BINDING PROTEIN PP2B PPASE-2B PROTEIN PHOSPHATASE 2B, HUMAN, RECOMBINANT, E COLI PROTEIN PHOSPHATASE 2B CAN CALMODULIN BINDING PROTEIN CALCINEURIN CALCINEURIN, HUMAN CALCINEURIN/PP2B Calcineurin bovine brain 90371-51-0