AR453588
- CAS No.
- 1065609-00-8
- Chemical Name:
- AR453588
- Synonyms
- AR453588;AR-453588,AR453588;Ethanone, 1-[4-[5-[[3-[(2-methyl-3-pyridinyl)oxy]-5-(2-pyridinylthio)-2-pyridinyl]amino]-1,2,4-thiadiazol-3-yl]-1-piperidinyl]-
- CBNumber:
- CB58054316
- Molecular Formula:
- C25H25N7O2S2
- Molecular Weight:
- 519.64
- MDL Number:
- MFCD34179486
- MOL File:
- 1065609-00-8.mol
- MSDS File:
- SDS
AR453588 Chemical Properties,Uses,Production
Biological Activity
AR453588 is a potent and orally bioavailable anti-diabetic glucokinase activator, with an EC50 of 42 nM. AR453588 shows anti-hyperglycemic activity[1]. AR453588 (3-30 mg/kg; p.o) lowers post-prandial glucose in normal C57BL/6J mice[1].AR453588 (3-30 mg/kg; p.o.; once-daily for 14 days) shows anti-hyperglycemic activity in a dose-ranging 14 day ob/ob mouse[1].AR453588 (10 mg/kg; p.o.) treatment shows that the Tmax, AUCinf, Vss, Cmax and F are 1.0 mL/min/kg, 4.65 h μg /mL, 1.67 μg /mL and 60.3%, respectively[1].AR453588 (1 mg/kg; i.v.) treatment shows that the CL, AUCinf, Vss, and t1/2 are 21.6 mL/min/kg, 0.77 h μg /mL, 0.746 L/kg and 1.28 hours, respectively[1].
References
[1]. Hinklin RJ, et al. Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator. Bioorg Med Chem. 2020 Jan 1;28(1):115232.
AR453588 Preparation Products And Raw materials
Raw materials
Preparation Products
AR453588 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Shanghai Anyinuo Biomedical Technology Co., Ltd. | 021-34625901 | 420970979@qq.com | China | 5861 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11975 | 58 |
RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9268 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19698 | 58 |