Vatalanib succinate
- CAS No.
- 212142-18-2
- Chemical Name:
- Vatalanib succinate
- Synonyms
- VATALANIB SUCCINATE;N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate;N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate;N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine butanedioate;butanedioicacid,N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
- CBNumber:
- CB5837212
- Molecular Formula:
- C24H21ClN4O4
- Molecular Weight:
- 464.9
- MDL Number:
- MFCD08435979
- MOL File:
- 212142-18-2.mol
| Melting point | 195° |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO |
| FDA UNII | V5FUB77031 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
Vatalanib succinate price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 5680 | Vatalanibsuccinate ≥99%(HPLC) | 212142-18-2 | 10 | $117 | 2021-12-16 | Buy |
| Tocris | 5680 | Vatalanibsuccinate ≥99%(HPLC) | 212142-18-2 | 50 | $491 | 2021-12-16 | Buy |
| TRC | V995035 | VatalanibSuccinate | 212142-18-2 | 50mg | $275 | 2021-12-16 | Buy |
| TRC | V995035 | VatalanibSuccinate | 212142-18-2 | 250mg | $815 | 2021-12-16 | Buy |
| TRC | V995035 | VatalanibSuccinate | 212142-18-2 | 100mg | $430 | 2021-12-16 | Buy |
Vatalanib succinate Chemical Properties,Uses,Production
Uses
Vatalanib Succinate is a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases.
Definition
ChEBI: A succinate salt obtained by combining vatalanib with one molar equivalent of succinic acid. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit.
in vivo
After oral dosing (50 mg/kg) to mice, plasma concentrations of Vatalanib (PTK787) remain above 1 μM for more than 8 h. Vatalanib (PTK787) induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model, as well as a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg)[1].
IC 50
KDR: 37 nM (IC50); Flt-1: 77 nM (IC50); Flt-4: 730 nM (IC50)
storage
Store at -20°C
Vatalanib succinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49984 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23912 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2123 | 70 |
View Lastest Price from Vatalanib succinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Vatalanib succinate
212142-18-2
|
US $2500.00-1520.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Vatalanib succinate
212142-18-2
- US $2500.00-1520.00 / mg
- TargetMol Chemicals Inc.