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Fmoc-Tyr(tBu)-OH

Fmoc-Tyr(tBu)-OH Structure
Fmoc-Tyr(tBu)-OH structure
CAS No.
71989-38-3
Chemical Name:
Fmoc-Tyr(tBu)-OH
Synonyms
FMOC-TYR(TBU)-OH;FMOC-TYR(TBU);Fmoc-Tyr(otbu)-OH;Tyr(tBu);FMOC-L-TYR(TBU)-OH;FMOC-TYR(TRT)-OH;FMOC-TYR(BUT);FMOC-L-TYROSINE(O-T-BUTYL);FMOC-L-TYR(TBU)-OH(71989-38-3);(2S)-3-[4-(tert-butoxy)phenyl]-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
CBNumber:
CB5854161
Molecular Formula:
C28H29NO5
Molecular Weight:
459.53
MDL Number:
MFCD08059708
MOL File:
71989-38-3.mol
MSDS File:
SDS
Last updated:2024-06-13 17:47:58
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Fmoc-Tyr(tBu)-OH Properties

Melting point ~150 °C (dec.)
alpha -28 º (c=1, DMF)
Boiling point 658.2±55.0 °C(Predicted)
Density 1.218±0.06 g/cm3(Predicted)
refractive index -30 ° (C=1, DMF)
storage temp. Store below +30°C.
solubility Chloroform (Slightly), DMF (Slightly), Methanol (Slightly)
pka 2.97±0.10(Predicted)
form Powder
color White
optical activity [α]20/D 29±2°, c = 1% in DMF
BRN 4216652
InChIKey JAUKCFULLJFBFN-VWLOTQADSA-N
SMILES C(O)(=O)[C@H](CC1=CC=C(OC(C)(C)C)C=C1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference 71989-38-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-24/25
WGK Germany  3
HS Code  2924 29 70
NFPA 704
1
2 0

Fmoc-Tyr(tBu)-OH price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.52020 Fmoc-Tyr(tBu)-OH Novabiochem? 71989-38-3 25g $90.1 2024-03-01 Buy
Sigma-Aldrich 8.52020 Fmoc-Tyr(tBu)-OH Novabiochem? 71989-38-3 100g $326 2024-03-01 Buy
Sigma-Aldrich 8.52020 Fmoc-Tyr(tBu)-OH Novabiochem? 71989-38-3 250g $687 2024-03-01 Buy
Sigma-Aldrich 8.52020 Fmoc-Tyr(tBu)-OH Novabiochem? 71989-38-3 1kg $2360 2024-03-01 Buy
Sigma-Aldrich 47623 Fmoc-Tyr(tBu)-OH ≥98.0% (HPLC) 71989-38-3 10g $65.9 2024-03-01 Buy
Product number Packaging Price Buy
8.52020 25g $90.1 Buy
8.52020 100g $326 Buy
8.52020 250g $687 Buy
8.52020 1kg $2360 Buy
47623 10g $65.9 Buy

Fmoc-Tyr(tBu)-OH Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystalline powder; insoluble in water and petroleum ether, soluble in ethyl acetate, methanol and DMF; mp is 150-151°C; specific optical rotation [α] 20D + 5.2° (0.5-2.0mg/ml, ethyl acetate ), [α]20D-27.6° (0.5-2.0 mg/ml, DMF), [α]20D-6° (0.5-2.0 mg/ml, methanol).

Uses

Fmoc-O-tert-butyl-L-tyrosine belongs to L-tyrosine compounds. Its molecular structure contains a chiral center, so it can exist two enantiomers and has optical activity. Fmoc-Tyr(tBu)-OH is used in peptide synthesis as amino acid protection monomer.

Preparation

To obtain Fmoc-Tyr(tBu)-OH, the following steps are carried out:
Suspend O-tert-butyl-L-tyrosine in a solution of dioxane.
Conduct an acylation reaction with fluorenyl methaneoxycarbonyl azide.
After the reaction, extract the crude product with ethyl acetate under pH 9-10 conditions.
Purify the extracted product through recrystallization.
This process results in the final product, Fmoc-Tyr(tBu)-OH.

General Description

Fmoc-Tyr(tBu)-OH is the preferred tyrosine derivative for solid phase peptide synthesis by Fmoc protocols. Protecting the Tyr sidechain may not be essential in the synthesis of small peptides. If the phenolic functional group of tyrosine does become acylated during a coupling reaction, the subsequent treatment with piperdine to remove Fmoc-groups will also remove any acylation of the phenolic function. Using Fmoc-Tyr(tBu)-OH in peptide synthesis is more efficient, however, since none of the activated amino acids are used unproductively in acylating exposed tyrosine side-chains. The use of Fmoc-Tyr(tBu)-OH also eliminates all potential for side products arising from the acylation of the tyrosine side-chain.

Fmoc-Tyr(tBu)-OH synthesis

60-18-4
71989-38-3
Synthesis of Fmoc-Tyr(tBu)-OH from L-Tyrosine

Fmoc-Tyr(tBu)-OH Preparation Products And Raw materials

Raw materials

Fluorene 1,4-Dioxane O-tert-Butyl-L-tyrosine

Preparation Products

Oxytocin ANGIOTENSIN I, HUMAN ANGIOTENSIN II, HUMAN FMOC-O-BUTYL-L-TYROSINE N-HYDROXYSUCCINIMIDE ESTER

Fmoc-Tyr(tBu)-OH Suppliers

Global( 491)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu ZY Biochemical Technology Co., Ltd.
+86-86-2888626688 +8618980008884 xuehaiying@zybiochem.com China 125 58
Wuhan senwayer century chemical Co.,Ltd 		+undefined-27-86652399 +undefined13627115097 market02@senwayer.com China 905 58
Chengdu Baishixing Science and Technology Industry Co.,Ltd 		+86-15008457246 +86-15008457246 yuki@cd-bsx.com China 53 58
Sichuan HongRi Pharma-Tech Co.,Ltd 		+86-028-64841719 +8617390183901 daisy@enlaibio.com China 1106 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29793 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18750 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32956 60
AB PharmaTech,LLC 		323-480-4688 sales@acrospharmatech.com United States 989 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Supplier Advantage
Chengdu ZY Biochemical Technology Co., Ltd.
58
Wuhan senwayer century chemical Co.,Ltd 		58
Chengdu Baishixing Science and Technology Industry Co.,Ltd 		58
Sichuan HongRi Pharma-Tech Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
AB PharmaTech,LLC 		55
career henan chemical co 		58

View Lastest Price from Fmoc-Tyr(tBu)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fmoc-L-Tyr(tBu)-OH pictures 2025-01-03 Fmoc-L-Tyr(tBu)-OH
71989-38-3
 US $0.00-0.00 / kg 1kg 98% 1T Sichuan HongRi Pharma-Tech Co.,Ltd
Fmoc-O-tert-butyl-L-tyrosine pictures 2025-01-03 Fmoc-O-tert-butyl-L-tyrosine
71989-38-3
 US $5.00 / kg 1kg ≥98% 500mt/year Jinan Finer Chemical Co., Ltd
Fmoc-O-tert-butyl-L-tyrosine pictures 2024-12-27 Fmoc-O-tert-butyl-L-tyrosine
71989-38-3
 US $0.00 / Kg/Bag 10g 98%min 100kgs WUHAN FORTUNA CHEMICAL CO., LTD

Fmoc-Tyr(tBu)-OH Spectrum

Fmoc-O-tert-butyl-L-tyrosine(71989-38-3)1HNMR

71989-38-3(Fmoc-Tyr(tBu)-OH)Related Search:

tert-Butyl methyl ether 4-tert-Butylphenol H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH L-Tyrosine 2-Butoxyethanol
Buprofezin Butyl acrylate Butyl acetate TYROSINASE butyl rubber
Fmoc-Aib-OH Cyhalofop-butyl 9-Fluorenylmethyl chloroformate PYRAZOPHOS tert-Butyldimethylsilyl chloride
Methyl 4-tert-butylbenzoate tert-Butyl hydroperoxide Nalpha-Fmoc-L-tyrosine

1of4

FMOC-L-TYROSINE (TBU) o-(tert-butyl)-n-[(9h-fluoren-9-ylmethoxy)carbonyl]-l-tyrosine O-TERT-BUTYL-NALPHA-FMOC-L-TYROSINE N-FMOC-T-BUTYL-L-TYR N-FMOC-O-T-BUTYL-L-TYROSINE N-ALPHA-FMOC-O-T-BUTYL-L-TYROSINE NALPHA-FMOC-O-TERT-BUTYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-T-BUTYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-O-TERT-BUTYL-L-TYROSINE NALPHA-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-O-TERT-BUTYL-L-TYROSINE N-(9-FLUORENYLMETHOXYCARBONYL)-O-TERT-BUTYL-L-TYROSINE N-9-FLUORENYLMETHYLOXYCARBONYL-O-T-BUTYL-L-TYROSINE N-9-FLUORENYLMETHYLOXYCARBONYL-O-TERT-BUTYL-L-TYROSINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-O-T-BUTYL-L-TYROSINE 9-FLUORENYLMETHOXYCARBONYL-O-T-BUTYL-L-TYROSINE L-Tyrosine-UL-13C9, 15N-N-FMOC N-(9-FLUORENYLMETHOXYCARBONYL)-2-TERT-BUTYL-L-TYROSINE NALPHA-9-Fluorenylmethoxycarbonyl-O-tert-butyl-L-tyrosine N-A-FMOC-O-T-BUTYL-L-TYROSINE FMOC-O-T-BUTYL-L-TYROSINE (FMOC-L-TYR(TBU)-OH) FMOC-O-TERT-BUTYL-L-TYROSINE 98+% N-tert-Butoxycarbonyl-O-(2-bromo-Cbz)-L-tyrosine L-TYROSINE-N-FMOC, O-TERT-BUTYL ETHER (13C9,15N) Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-tyrosine Fmoc-O-tert-butyl-L-tyrosine≥ 99.7% (HPLC, Chiral purity) (9-fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine Fmoc-O-tert-butyl-L-tyrosine, N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-tyrosine FMOC-L-TYR(O-T-BUTYL) FMOC-L-TYR(T-BU) 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid N-(9-Fluorenylmethoxycarbonyl)-o-tert-butyl-L-tyrosine ,98% 4-tert-Butoxy-Fmoc-Phe-OH N-(9H-Fluorene-9-ylmethoxycarbonyl)-O-tert-butyl-L-tyrosine N-(9H-Fluorene-9-ylmethoxycarbonyl)-O-tert-butyltyrosine O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tyrosine O-tert-Butyl-N-(9H-fluorene-9-ylmethoxycarbonyl)-L-tyrosine O-tert-Butyl-N-(9H-fluorene-9-ylmethoxycarbonyl)tyrosine Fmoc-(O-terbutyl)Tyrosine Fmoc-O-tert-butyl-L- FMco-Tyr(tBu)-OH L-TYROSINE-N-FMOC, O-TERT-BUTYL ETHER O-tert-Butyl-Nalpha-Fmoc-L-tyrosine Nalpha-Fmoc-O-tert-butyl-L-tyrosine Fmoc-Tyr(tBu)-OH N^a-FMoc-O-tert-butyl-L-tyrosine, 98% Fmoc-Tyr(tBu)-OH >=98.0% (HPLC) FMOC-TYR(BUT)-OH FMOC-TYROSINE(TBU)-OH FMOC-O-T-BUTYL-L-TYROSINE FMOC-O-TERT-BUTYL-L-TYROSINE (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(4-(tert-butoxy)phenyl)propanoic acid (9H-Fluoren-9-yl)MethOxy]Carbonyl Tyr(tBu)-OH Fomc-Tyrs( Fomc-Tyrs(tBu)-OH Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-tyrosine> FMOC-TYR(TBU)-OH 100 G FMOC-TYR(TBU)-OH 25 G FMOC-TYR(TBU)-OH 250 G L-Tyrosine, O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- Fmoc-O-tert-butyl-L-tyrosine USP/EP/BP