niceritrol

Originator

Cardiolipol,Gremy-Longuet,France,1972

Manufacturing Process

160 grams of nicotinic acid chloride is charged into and made to react with 35 grams of pentaerythritol dissolved in 600 grams of dried, stabilized chloroform and 100 grams of carefully dried pyridine. Pyridine hydrochloride, pyridine and the excess of nicotinic acid chloride are removed through repeated extraction with water at a pH of approximately 3. Pentaerythritol nicotinate remains in the chloroform phase and is extracted by forming the hydrochloric acid salt of the ester using 1,000 ml of aqueous HCl at a pH of 1. The strongly acid extract is thereafter extracted several times with toluene. The acid extract is allowed to stand at room temperature for several hours in the presence of active carbon and the substance known as Versenate, i.e., the disodium salt of ethylene diamine tetraacetic acid; it is then filtered and pentaerythritol nicotinate is precipitated as a white, amorphous substance using 25% w/v aqueous ammonia, while stirring. Recrystallization of the product from ethyl alcohol gives flaky crystals, according to British Patent 1,022,880.

Therapeutic Function

Antihyperlipidemic

Raw materials

Preparation Products