ChemicalBook >> CAS DataBase List >>INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED structure

CAS No.: 2304465-89-0

Chemical Name:: INDEX NAME NOT YET ASSIGNED

Synonyms: F5446;1-benzyl 7-methyl 6-(4-chlorobenzenesulfonyl)-4,5-dioxo-3H,4H,5H,6H-pyrrolo[3,2-e]indole-1,7-dicarboxylate;1-Benzyl 7-methyl 6-((4-chlorophenyl)sulfonyl)-4,5-dioxo-3,4,5,6-tetrahydropyrrolo[3,2-e]indole-1,7-dicarboxylate

CBNumber:: CB59272139

Molecular Formula:: C26H17ClN2O8S

Molecular Weight:: 552.94

MDL Number:

MOL File:: 2304465-89-0.mol

Last updated:2024-07-02 08:55:12

Request For Quotation

INDEX NAME NOT YET ASSIGNED Properties

Boiling point	838.4±75.0 °C(Predicted)
Density	1.56±0.1 g/cm3(Predicted)
pka	11.47±0.20(Predicted)
form	Solid
color	Orange to reddish brown

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Description

F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby upregulating expression of these effectors in tumor-infiltrating CTLs and suppressing colon carcinoma growth in a CD8+ CTL-dependent manner in vivo. Our data indicate that SUV39H1 represses CTL effector gene expression and, in doing so, confers colon cancer immune escape.

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 7)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4351	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62163	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24647	58
ZhengZhou Edward Biology Co.,Ltd	13298105281 13298105281	1522334715@qq.com	China	7511	58
Elucigen bio	13501719342	wayne.zheng@elucigenbio.com	China	4587	58

Supplier	Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai EFE Biological Technology Co., Ltd.	58
Bide Pharmatech Ltd.	58
TargetMol Chemicals Inc.	58
ZhengZhou Edward Biology Co.,Ltd	58
Elucigen bio	58

F5446 1-Benzyl 7-methyl 6-((4-chlorophenyl)sulfonyl)-4,5-dioxo-3,4,5,6-tetrahydropyrrolo[3,2-e]indole-1,7-dicarboxylate 1-benzyl 7-methyl 6-(4-chlorobenzenesulfonyl)-4,5-dioxo-3H,4H,5H,6H-pyrrolo[3,2-e]indole-1,7-dicarboxylate 2304465-89-0 C26H17ClN2O8S