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TP0586532

TP0586532 structure

CAS No.: 2427584-96-9

Chemical Name:: TP0586532

Synonyms: TP0586532;3-Azabicyclo[3.1.0]hexane-3-butanoic acid, 6-[2-[4-[3-[[2-[(1S)-1-hydroxyethyl]-1H-imidazol-1-yl]methyl]-5-isoxazolyl]phenyl]ethynyl]-, (1α,5α,6-exo,6α)-

CBNumber:: CB59722861

Molecular Formula:: C26H28N4O4

Molecular Weight:: 460.53

MDL Number:: MFCD34567328

MOL File:: 2427584-96-9.mol

Last updated:2024-07-02 08:55:12

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TP0586532 Properties

Boiling point	712.1±60.0 °C(Predicted)
Density	1.36±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 50 mg/mL (108.57 mM; Need ultrasonic)
form	Solid
pka	4.44±0.10(Predicted)
color	White to off-white

TP0586532 Chemical Properties,Uses,Production

Biological Activity

TP0586532 is a non-hydroxamate LpxC inhibitor (IC50=0.101 μM). TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1]. TP0586532 as a compound with a low cardiovascular risk that is effective against K. pneumoniae, including resistant strains[1].

References

[1]. Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021;30:115964.

TP0586532 Preparation Products And Raw materials

Raw materials

Preparation Products

TP0586532 Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	15317229551	15151849396@163.com	China	996	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	lucy@atkchemical.com	China	9952	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9409	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24644	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9266	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd	58
ShangHai Biochempartner Co.,Ltd	62
Shanghai SuperLan Chemcial Technique Centre	58
DC Chemicals	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
RD International Technology Co., Limited	58

TP0586532 3-Azabicyclo[3.1.0]hexane-3-butanoic acid, 6-[2-[4-[3-[[2-[(1S)-1-hydroxyethyl]-1H-imidazol-1-yl]methyl]-5-isoxazolyl]phenyl]ethynyl]-, (1α,5α,6-exo,6α)- 2427584-96-9