GW 3965 HYDROCHLORIDE
- CAS No.
- 405911-17-3
- Chemical Name:
- GW 3965 HYDROCHLORIDE
- Synonyms
- CS-742;GW3965 HCl;GW3965 HCl Salt;W 3965 HYDROCHLORIDE;GW3965 hydrochloride, >=98%;GW-3965 hydrochloride GW3965;GW 3965 hydrochloride, LXR agonist;GW3965 hydrochloride, 10 mM in DMSO;GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…
- CBNumber:
- CB5972490
- Molecular Formula:
- C33H31ClF3NO3.HCl
- Molecular Weight:
- 0
- MDL Number:
- MFCD08276920
- MOL File:
- 405911-17-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318-H413 | |||||||||
| Precautionary statements | P264-P270-P273-P280-P301+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
GW 3965 HYDROCHLORIDE price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G6295 | GW3965 hydrochloride ≥98% (HPLC), powder | 405911-17-3 | 5mg | $206 | 2024-03-01 | Buy |
| Sigma-Aldrich | G6295 | GW3965 hydrochloride ≥98% (HPLC), powder | 405911-17-3 | 25mg | $702 | 2024-03-01 | Buy |
| Cayman Chemical | 10054 | GW 3965 (hydrochloride) ≥98% | 405911-17-3 | 1mg | $39 | 2024-03-01 | Buy |
| Cayman Chemical | 10054 | GW 3965 (hydrochloride) ≥98% | 405911-17-3 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 10054 | GW 3965 (hydrochloride) ≥98% | 405911-17-3 | 10mg | $175 | 2024-03-01 | Buy |
GW 3965 HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.
Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
in vivo
GW3965 hydrochloride induces an increase of neuroactive steroids in the spinal cord, the cerebellum and the cerebral cortex of STZ-rats, but not in the CNS of non-pathological animals. GW3965 hydrochloride treatment induces an increase of dihydroprogesterone in the spinal cord of diabetic animals in association with an increase of myelin basic protein expression[1]. GW3965 hydrochloride (40 mg/kg, p.o.) strongly induces ABCA1 expression and reduces LDLR expression, and this is accompanied by 59% inhibition of tumor growth, and a 25-fold increase in GBM cell apoptosis in vivo[2]. GW3965 hydrochloride (2 mg/kg, i.v.) increases bleeding time and modulated platelet thrombus formation in vivo[3].
storage
Desiccate at RT
GW 3965 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7906 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 | chem1022@hengdian-group.com | China | 1478 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 13194 | 58 |
View Lastest Price from GW 3965 HYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | GW3965 HCl
405911-17-3
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2024-11-19 | GW3965 hydrochloride
405911-17-3
|
US $35.00-90.00 / mg | 99.51% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-09 | GW 3965 HYDROCHLORIDE
405911-17-3
|
US $1.00 / KG | 1KG | 85.0-99.8% | 20tons | Career Henan Chemical Co |
-
- GW3965 HCl
405911-17-3
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- GW3965 hydrochloride
405911-17-3
- US $35.00-90.00 / mg
- 99.51%
- TargetMol Chemicals Inc.
-
- GW 3965 HYDROCHLORIDE
405911-17-3
- US $1.00 / KG
- 85.0-99.8%
- Career Henan Chemical Co