ChemicalBook >> CAS DataBase List >>Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]-
Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]-
![Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Structure](CAS/20210305/GIF/2231760-33-9.gif)
- CAS No.
- 2231760-33-9
- Chemical Name:
- Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]-
- Synonyms
- Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]-
- CBNumber:
- CB59821151
- Molecular Formula:
- C20H23N3O2S
- Molecular Weight:
- 369.48
- MDL Number:
- MFCD34469346
- MOL File:
- 2231760-33-9.mol
Last updated:2024-07-02 08:55:12
Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Properties
| Density | 1.314±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (135.33 mM; Need ultrasonic) |
| pka | 9.49±0.50(Predicted) |
| form | Solid |
| color | White to off-white |
Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Chemical Properties,Uses,Production
Biological Activity
AZ2 is a highly selective PI3Kγ inhibitor (The pIC50 value for PI3Kγ is 9.3). AZ2 can be used for the research of inflammatory and immune diseases[1]. AZ2 (0.1~100 nM; 1 hour; SKOV-3 cells) excellent selectivity for PI3Kγ is further confirmed with a constitutively activated PI3K/Akt pathway[1].
References
[1]. Gangadhara G, et al. A class of highly selective inhibitors bind to an active state of PI3Kγ. Nat Chem Biol. 2019;15(4):348-357.
Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]- Suppliers
Global( 6)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2497 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4399 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5014 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9155 | 58 |
Acetamide, N-[5-[2-[(1S)-1-cyclopropylethyl]-2,3-dihydro-7-methyl-1-oxo-1H-isoindol-5-yl]-4-methyl-2-thiazolyl]-
2231760-33-9