E-7820
- CAS No.
- 289483-69-8
- Chemical Name:
- E-7820
- Synonyms
- E-7820;CS-2701;ER 68203-00;E 7820; E-7820;ER68203-00;E7820;E-7820;E 7820;289483-69-8;3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide;N-(3-cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide;Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-;E7820,cell,tumor,WiDr,derivative,Integrin,colorectal,LoVo,inhibit,Inhibitor,sulfonamide,HUVEC,endothelium,E 7820,E-7820;3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239
- CBNumber:
- CB61011214
- Molecular Formula:
- C17H12N4O2S
- Molecular Weight:
- 336.37
- MDL Number:
- MFCD09833234
- MOL File:
- 289483-69-8.mol
- MSDS File:
- SDS
Boiling point | 626.2±65.0 °C(Predicted) |
---|---|
Density | 1.48±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO:67.0(Max Conc. mg/mL);199.19(Max Conc. mM) |
form | A crystalline solid |
pka | 8.17±0.30(Predicted) |
color | Light yellow to light brown |
FDA UNII | TVH5K7949N |
NCI Drug Dictionary | E7820 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
E-7820 price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 25502 | E7820 ≥98% | 289483-69-8 | 5mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 25502 | E7820 ≥98% | 289483-69-8 | 10mg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 25502 | E7820 ≥98% | 289483-69-8 | 50mg | $283 | 2024-03-01 | Buy |
Cayman Chemical | 25502 | E7820 ≥98% | 289483-69-8 | 100mg | $530 | 2024-03-01 | Buy |
Tocris | 6785 | E7820 ≥98%(HPLC) | 289483-69-8 | 10 | $207 | 2021-12-16 | Buy |
E-7820 Chemical Properties,Uses,Production
Description
E7820 is a sulfonamide derivative and an angiogenesis inhibitor that inhibits bFGF- and VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation (IC50s = 0.1 and 0.081 μg/ml, respectively). It inhibits bFGF- and VEGF-stimulated tube formation of HUVECs in a concentration-dependent manner (IC50s = 0.2 and 0.24 μg/ml, respectively). E7820 selectively decreases the surface expression and mRNA levels of integrin α2 over CD31 and VE-cadherin in HUVECs. In vivo, E7820 (200 and 400 mg/kg) reduces tumor growth and inhibits angiogenesis in a WiDr colorectal cancer mouse xenograft model. It also reduces tumor weight in a panel of seven human colon, breast, pancreas, and kidney cancer mouse xenograft models, completely inhibits tumor growth in KP-1 pancreatic and LoVo colon cancer mouse xenograft models, and inhibits tumor growth in KP-1 and COLO 320DM mouse orthotopic transplantation models.
storage
Store at -20°C
E-7820 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 907 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |