1-METHYLURIC ACID
- CAS No.
- 708-79-2
- Chemical Name:
- 1-METHYLURIC ACID
- Synonyms
- 1-U;1MUA;1-METHYLURIC ACID;1-Methyluric acid ,98%;Theophylline Impurity 17;1-METHYLURIC ACID USP/EP/BP;1-METHYL-2,6,8-TRIHYDROXYPURINE;1-Methyl-1H-purine-2,6,8(3H,7H,9H)-trione;1-methyl-7,9-dihydro-3H-purine-2,6,8-trione;7,9-dihydro-1-methyl-1H-purine-2,6,8(3H)-trione
- CBNumber:
- CB6107257
- Molecular Formula:
- C6H6N4O3
- Molecular Weight:
- 182.14
- MDL Number:
- MFCD00042987
- MOL File:
- 708-79-2.mol
| Melting point | >325°C |
|---|---|
| Boiling point | 315.51°C (rough estimate) |
| Density | 1.5283 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| storage temp. | Refrigerator |
| solubility | Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated, Sonicated) |
| form | Solid |
| pka | 5.60±0.50(Predicted) |
| color | Pale Yellow to Pale Brown |
| Water Solubility | 1.585g/L(temperature not stated) |
| BRN | 195190 |
| FDA UNII | 2WS4HQ639J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| WGK Germany | 3 |
| HS Code | 29242990 |
1-METHYLURIC ACID price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M6885 | 1-Methyluric acid | 708-79-2 | 50mg | $146 | 2023-01-07 | Buy |
| Sigma-Aldrich | M6885 | 1-Methyluric acid | 708-79-2 | 100mg | $259 | 2023-01-07 | Buy |
| Usbiological | 017570 | 1-Methyluric Acid | 708-79-2 | 10mg | $340 | 2021-12-16 | Buy |
| Usbiological | 281677 | 1-Methyluric acid | 708-79-2 | 25mg | $375 | 2021-12-16 | Buy |
| TRC | M338180 | 1-Methyluric acid | 708-79-2 | 25mg | $135 | 2021-12-16 | Buy |
1-METHYLURIC ACID Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
1-Methyluric acid, a metabolite of Theophylline, has been used:
for the determination of uric acid in stool samples by liquid chromatography and tandem mass spectrometry
in turbidimetric assay of synthetic urine samples
as a substrate for CYP1A2(cytochrome P450 family 1 subfamily A member 2) assay
Definition
ChEBI: An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by a methyl group at N-1. It is one of the metabolites of caffeine found in human urine.
Biochem/physiol Actions
1-Methyluric acid (1-U) is a major metabolite of caffeine and theophylline with antioxidant activity that protects molecules such as low density lipoproteins (LDL) from oxidative modifications. 1-Methyluric acid may be used in studies aimed at differentiating the activities of caffeine and theophylline metabolites.
Purification Methods
Recrystallise it from H2O. Its solubility at 17.5o is 1g in 353mL of H2O. [Bergmann & Dikstein J Am Chem Soc 77 691 1955.] It has UV: max at 231 and 283nm (pH 3), and 217.5 and 292.5nm (pH >12) [Johnson Biochem J 5 133 1952]. [Beilstein 26 II 299, 26 III/IV 2621.]
1-METHYLURIC ACID Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1-METHYLURIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94657 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12984 | 57 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | meilunui@163.com | China | 4727 | 58 |
| Synchem OHG | +49 5662 408730 | info@synchem.de | Germany | 4705 | 70 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb6@aikonchem.com | China | 16684 | 50 |