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Calpain Inhibitor I

Calpain Inhibitor I structure

CAS No.: 110044-82-1

Chemical Name:: Calpain Inhibitor I

Synonyms: ALLN;LLNL;MG 101;ac-llnl-cho;MG-101 (ALLN);InSolution? ALLN;Ac-Leu-Leu-Nle-al;AC-LL-NORLEUCINAL;CALPAIN INHIBITOR;AC-LEU-LEU-NLE-CHO

CBNumber:: CB6108214

Molecular Formula:: C20H37N3O4

Molecular Weight:: 383.53

MDL Number:: MFCD00065505

MOL File:: 110044-82-1.mol

Last updated:2024-11-19 15:53:33

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Calpain Inhibitor I Properties

Melting point	182 °C
Boiling point	510.42°C (rough estimate)
Density	1.1322 (rough estimate)
refractive index	1.6300 (estimate)
storage temp.	2-8°C
solubility	DMSO: soluble
form	powder
pka	13.53±0.46(Predicted)
color	white
Water Solubility	Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
BRN	7656053
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P280
Safety Statements	22-24/25
WGK Germany	3
F	3-10
HS Code	29241900

Calpain Inhibitor I price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	208719	ALLN	110044-82-1	5mg	$117	2024-03-01	Buy
Sigma-Aldrich	208719	ALLN	110044-82-1	25mg	$303	2024-03-01	Buy
Sigma-Aldrich	11086090001	Calpain Inhibitor I N-Acetyl-Leu-Leu-norleucinal,synthetic	110044-82-1	25mg	$343	2024-03-01	Buy
Alfa Aesar	J61766	Calpain Inhibitor I, 95+%	110044-82-1	5mg	$91.8	2023-06-20	Buy
Cayman Chemical	14921	Calpain Inhibitor I ≥95%	110044-82-1	1mg	$31	2024-03-01	Buy

Product number	Packaging	Price	Buy
208719	5mg	$117	Buy
208719	25mg	$303	Buy
11086090001	25mg	$343	Buy
J61766	5mg	$91.8	Buy
14921	1mg	$31	Buy

Calpain Inhibitor I Chemical Properties,Uses,Production

Description

ALLN (110044-82-1) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190 nM), calpain II (Ki=150 nM), cathepsin L (Ki=0.5 nM) and other neutral cysteine proteases.1?Inhibits cell cycle progression at G1/S?and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.2?Inhibits proteolytic degradation of IκBα and IκBβ in RAW macrophages induced with LPS.3?Blocks AIF-mediated necroptosis.4?Cell permeable.

Chemical Properties

white to off-white powder

Uses

It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.

Uses

Calpain inhibitor I reversibly blocks the calcium-dependent neutral cysteine protease calpain I. Calpains have been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.

Uses

Calpain inhibitor I inhibits calpain, which activates myosin light chain kinase and protein kinase C by partial proteolysis. The inhibitor should be membrane permeable due to low molecular weight and lack of charged residues.
Calpain Inhibitor I is used for western blotting methods.

Definition

ChEBI: A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence.

General Description

Calpain Inhibitor I is a strong, competitive inhibitor of the Ca²⁺-dependent neutral cysteine proteases calpain I and calpain II.

Biological Activity

Calpain inhibitor (IC 50 = 0.09 μ M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.

Biochem/physiol Actions

Calpain Inhibitor I inhibits tumor necrosis factor-induced (TNF-induced) cleavage of Poly (ADP-ribose) polymerase (PARP) and calpastatin in apoptosis. It also inhibits oxygen/glucose deprivation (OGD) induced cleavage of caspase-12 and Bcl-xL..

References

1) Sasaki?et al.?(1990),?Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins; J. Enzyme Inhib.?3?195 2) Sherwood?et al. (1993)?In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal; Proc. Natl. Acad. Sci USA?90?3353 3) Schow and Joly (1997),?N-acetyl-leucinyl-leucinyl-norleucinal inhibits lipopolysaccharide-induced NF-kappaB activation and prevents TNF and IL-6 synthesis in vivo; Cell Immunol.?175?199 4) Shang?et al.?(2014)?Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure; BMC Neurosci.?15?63

Calpain Inhibitor I Preparation Products And Raw materials

Raw materials

Preparation Products

Calpain Inhibitor I Suppliers

Global( 115)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
Wuhan Han Sheng New Material Technology Co.，Ltd	+8617798174412	admin01@hsnm.com.cn	China	2097	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
ANHUI WITOP BIOTECH CO., LTD	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Wuhan Han Sheng New Material Technology Co.，Ltd	58
Aladdin Scientific	58
Aladdin Scientific	58

View Lastest Price from Calpain Inhibitor I manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	MG-101 110044-82-1	US $48.00-157.00 / mg		≥98%	10g	TargetMol Chemicals Inc.

MG-101
110044-82-1
US $48.00-157.00 / mg
≥98%
TargetMol Chemicals Inc.

Calpain Inhibitor I Spectrum

ALLN(110044-82-1)MS

110044-82-1(Calpain Inhibitor I)Related Search:

Calpain Inhibitor I CALPAIN INHIBITOR I,CALPAIN INHIBITOR CALPAIN INHIBITOR IV CALPAIN INHIBITOR III MET-ALA-GLY-ARG-SER-GLY-ASP-SER-ASP-GLU-ASP-LEU-LEU-LYS-ALA-VAL

(TYR0)-KALIURETIC PEPTIDE (HUMAN) H-PRO-ALA-VAL-ASP-LEU-LEU-LYS-ASN-TYR-MET-GLN-LEU-GLY-LYS-GLN-OH ASP-GLU-ASP-LEU-LEU-LYS-ALA-VAL-ARG-LEU-ILE-LYS-PHE-LEU-TYR-GLN-SER-ASN PEPTITERGENT PD1 H-PRO-PRO-GLU-ASP-PRO-ALA-VAL-ASP-LEU-LEU-LYS-ASN-TYR-MET-GLN-LEU-GLY-LYS-GLN-GLN-OH

H-MET-PRO-THR-ALA-PRO-PRO-GLU-ASP-PRO-ALA-VAL-ASP-LEU-LEU-LYS-OH KALIURETIC PEPTIDE (HUMAN) SPFK H-SER-LEU-LEU-LYS-OH H-PRO-PRO-GLU-ASP-PRO-ALA-VAL-ASP-LEU-LEU-LYS-ASN-TYR-MET-GLN-OH

PREPRO-ANF (104-116), HUMAN PSTAIR peptide GLU-ASP-LEU-LEU-LYS-ALA-VAL-ARG-LEU-ILE-LYS

1of4

AC-LEU-LEU-NLE-H (ALDEHYDE) AC-LEU-LEU-NORLEUCINAL AC-LL-NORLEUCINAL ac-llnl-cho Ac-Leu-Leu-Nle-al Ac-LLnL-CHO, ALLN, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal Calpain Inhibitor I,96% N-Acetyl-L-leucine-L-leucine-L-norleucinal N-Acetyl-Leu-Leu-Norleu-al Calpain Inhibitor I, ALLN ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal Calpain Inhibitor Ⅰ 〔N-Acetyl-L-leucyl-L-leucyl-L-norleucinal〕 InSolution? ALLN MG-101 (ALLN) N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-Leucinamide ALLN acetylleucyl-leucyl-norleucinal N-AC-LEU-LEU-NORLEUCINAL N-ACETYL-LEU-LEU-NLE-CHO N-ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL N-ACETYL-LEU-LEU-NORLEUCINAL MG 101 LLNL CALPAIN INHIBITOR CALPAIN INHIBITOR I ACETYL-LEU-LEU-NORLEUCINAL ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL AC-LEU-LEU-L-NORLEUCINAL AC-LEU-LEU-NLE-ALDEHYDE AC-LEU-LEU-NLE-CHO CALPAIN INHIBITOR I;AC-LLNL-CHO;ALLN (S)-2-acetamido-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-4-methyl-N-((S)-1-oxohexan-2-yl)pentanamide L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]- MG-101 (Calpain inhibitor I InSolution ALLN - CAS 110044-82-1 - Calbiochem ALLN - CAS 110044-82-1 - Calbiochem CALPAIN INHIBITOR-1;MG101;MG-101;MG 101 CALPAIN INHIBITOR I RKO,MG-101,colon cancer,Bax,HepG2,Proteasome,MG 101,Inhibitor,mitochondria,HCT116,inhibit,Apoptosis,SW480,anti-tumor N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal ALLN (DMSO solution) 110044-82-1 C20H37N3O4 Enzyme Inhibitors by Type BioChemical Biochemicals and Reagents Calpain I A to C Substrate Analogs Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates inhibitor peptides ProteasomeInhibitors C-CH Cell Biology