5-hydroxy-l-tryptophan
- CAS No.
- 314062-44-7
- Chemical Name:
- 5-hydroxy-l-tryptophan
- Synonyms
- 5-HYDROXY-L-TRYPTOPHAN;5-HTP;L-5-HTP;L-HTP-OH;H-TRP(5-OH)-OH;5-HYDROXY-TRP-OH;H-5-HYDROXY-TRP-OH;5-HYDROXY-L-TRP-OH;C5-HYDROXY-L-TRYPTOPHAN;L-5-HYDROXYTRYPTOPHAN HYDRATE
- CBNumber:
- CB6110024
- Molecular Formula:
- C11H12N2O3
- Molecular Weight:
- 220.22
- MDL Number:
- MFCD00064341
- MOL File:
- 314062-44-7.mol
- MSDS File:
- SDS
| Melting point | 270 °C (dec.)(lit.) |
|---|---|
| Density | 0.902 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 175 °F |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | H2O: 10 mg/mL |
| form | solid |
| color | white |
| InChI | InChI=1/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/s3 |
| InChIKey | LDCYZAJDBXYCGN-DJEYLCQNNA-N |
| SMILES | C12C=C(C=CC=1NC=C2C[C@H](N)C(=O)O)O |&1:10,r| |
| CAS DataBase Reference | 314062-44-7(CAS DataBase Reference) |
5-hydroxy-l-tryptophan price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CCH0000443 | L-5-HYDROXYTRYPTOPHAN HYDRATE 95.00% | 314062-44-7 | 250MG | $567.93 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0000443 | L-5-HYDROXYTRYPTOPHAN HYDRATE 95.00% | 314062-44-7 | 1G | $643.37 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0000443 | L-5-HYDROXYTRYPTOPHAN HYDRATE 95.00% | 314062-44-7 | 5G | $889.68 | 2021-12-16 | Buy |
| Chemenu | CM192656 | (S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoicacidhydrate 95% | 314062-44-7 | 100g | $466 | 2021-12-16 | Buy |
| Crysdot | CD21008743 | (S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoicacidhydrate 95+% | 314062-44-7 | 100g | $493 | 2021-12-16 | Buy |
5-hydroxy-l-tryptophan Chemical Properties,Uses,Production
Description
5-hydroxy-l-tryptophan (5-HTP) is a chemical byproduct of the protein building block L-tryptophan. It is produced commercially from the seeds of an African plant known as Griffonia simplicifolia. In vivo, it is produced from tryptophan by tryptophan hydroxylase (TPH), and its decarboxylation yields serotonin (5-hydroxytryptamine, 5-HT), a monoamine neurotransmitter involved in the modulation of mood, cognition, reward, learning, memory, sleep, and numerous other physiological processes. 5-HTP is both a drug and a natural component of some dietary supplements, and occurrence in both synthetic tryptophan and 5-HTP of toxic impurities has caused eosinophilia myalgia syndrome cases[1].
History
5-hydroxy-l-tryptophan (5-HTP) has been used clinically for more than 30 yr. Sales and awareness of 5-HTP increased in 1989 after the Food and Drug Administration (FDA) banned its precursor, L-tryptophan, because of its association with eosinophilia-myalgia syndrome. Since then, 5-HTP has been marketed as a safe alternative to L-tryptophan.
Uses
5-hydroxy-l-tryptophan is metabolized into serotonin and is thought to alleviate depression by enhancing serotonin neurotransmission. It is also used to treat fibromyalgia, insomnia, binge-eating, attention deficit disorder, and chronic headaches.
Side effects
Administration of 5-hydroxy-l-tryptophan in patients with major depression who received selective serotonin reuptake inhibitors like fluoxetine resulted in significantly increased levels of cortisol and prolactin in plasma compared with untreated depressed patients, suggesting that the adverse effect of 5-hydroxy-l-tryptophan was potentiated by fluoxetine. The main side effects of 5-hydroxy-l-tryptophan are dose-related, and sleepiness, fatigue, nausea, or vomiting are the most cited.
Metabolism
5-Hydroxy-l-tryptophan is a precursor for melatonin (N-acetyl-5-methoxytryptamine, a regulatory hormone of circadian rhythm) that is synthesized from serotonin via N-acetyl-serotonin. It is transported to various body tissues, including the brain, where it is transformed into serotonin. The absorption of 5-hydroxy-tryptophan and its decarboxylation to serotonin are processes of variable efficiencies (47%–84%). The serotonin is metabolized sequentially to its inactive metabolites, and it is excreted in the form of 5-hydroxyindoleacetic acid.
References
[1] Maffei, Massimo E. "5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology." International Journal of Molecular Sciences 22.1(2021):181.
5-hydroxy-l-tryptophan Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hong Kong Excellence Biotechnology Co., Ltd. | ada@sh-teruiop.com | China | 882 | 58 | |
| Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 491 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 346 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 | sales@fine-chemtech.com | CHINA | 885 | 55 |
| Jinan Jianfeng Chemical Co., Ltd | +8615562555968 | info@pharmachemm.com | China | 243 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19372 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from 5-hydroxy-l-tryptophan manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-03 | 5-HTP
314062-44-7
|
US $0.00 / KG | 1KG | 98.0% | 500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-09-03 | 5-HYDROXY-L-TRYPTOPHAN
314062-44-7
|
US $1.00 / g | 1g | 99.9+% | 20T | Jinan Jianfeng Chemical Co., Ltd | |
 |
2024-08-07 | L-5HTP
314062-44-7
|
US $100.00 / kg | 1kg | >99% | 20tons | Hong Kong Excellence Biotechnology Co., Ltd. |
-
- 5-HTP
314062-44-7
- US $0.00 / KG
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 5-HYDROXY-L-TRYPTOPHAN
314062-44-7
- US $1.00 / g
- 99.9+%
- Jinan Jianfeng Chemical Co., Ltd
-
- L-5HTP
314062-44-7
- US $100.00 / kg
- >99%
- Hong Kong Excellence Biotechnology Co., Ltd.