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RUVBL1/2 ATPase-IN-1

RUVBL1/2 ATPase-IN-1 Structure
RUVBL1/2 ATPase-IN-1 structure
CAS No.
423128-55-6
Chemical Name:
RUVBL1/2 ATPase-IN-1
Synonyms
RUVBL1/2 ATPase-IN-1;RUVBL1/2 ATPaseIN1,inhibit,Inhibitor,selective,RUVBL1/2 ATPase IN 1,cancer,RUVBL1,AAA ATPases,RUVBL2;1-{5,7-dimethyl-6-[(4-methylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-3-carbonyl}-4-[3-(trifluoromethyl)phenyl]piperazine;Methanone, [5,7-dimethyl-6-[(4-methylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-3-yl][4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-
CBNumber:
CB611086211
Molecular Formula:
C28H28F3N5O
Molecular Weight:
507.55
MDL Number:
MOL File:
423128-55-6.mol
Last updated:2025-04-17 18:22:24
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RUVBL1/2 ATPase-IN-1 Properties

Density 1.29±0.1 g/cm3(Predicted)
storage temp. 4°C, protect from light
solubility DMSO : 10 mg/mL (19.70 mM; ultrasonic and warming and heat to 60°C)
pka 1.33±0.20(Predicted)
form Solid
color White to off-white

RUVBL1/2 ATPase-IN-1 Chemical Properties,Uses,Production

Uses

RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases[1].

Biological Activity

RUVBL1/2 ATPase-IN-1 (compound 18) is a potent and selective inhibitor of RUVBL1/2 ATPase with IC50 values of 6.0 and 7.7 μM, respectively. RUVBL1 and RUVBL2 are highly conserved AAA ATPases (ATPases Associated with various cellular Activities) and highly relevant to the progression of cancer. RUVBL1/2 ATPase-IN-1 has the potential for the research of cancer diseases[1].

References

[1]. Zhang G, et al. Discovery of small-molecule inhibitors of RUVBL1/2 ATPase. Bioorg Med Chem. 2022;62:116726.

RUVBL1/2 ATPase-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

RUVBL1/2 ATPase-IN-1 Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71829 60
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9330 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Jingmo (Xiamen) Biotechnology Co., Ltd 13621943973; 13621943973 sales@jamxmpharmatech.com China 1131 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24642 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 7165 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Hubei wei shi reagent group ltd., company 027-59101766 13125137661 2853877621@qq.com China 7979 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 025-66061636 18013972705 qqyang@aikonchem.com China 10152 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
DC Chemicals 58
Jingmo (Xiamen) Biotechnology Co., Ltd 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Hubei wei shi reagent group ltd., company 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. 58

RUVBL1/2 ATPase-IN-1 Spectrum

RUVBL1/2 ATPase-IN-1(423128-55-6)1HNMR
RUVBL1/2 ATPase-IN-1 RUVBL1/2 ATPaseIN1,inhibit,Inhibitor,selective,RUVBL1/2 ATPase IN 1,cancer,RUVBL1,AAA ATPases,RUVBL2 Methanone, [5,7-dimethyl-6-[(4-methylphenyl)methyl]pyrazolo[1,5-a]pyrimidin-3-yl][4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]- 1-{5,7-dimethyl-6-[(4-methylphenyl)methyl]pyrazolo[1,5-a]pyrimidine-3-carbonyl}-4-[3-(trifluoromethyl)phenyl]piperazine 423128-55-6