Zetidoline
- CAS No.
- 51940-78-4
- Chemical Name:
- Zetidoline
- Synonyms
- MDL-308;Zetidoline;1-(3-Chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-yl)ethyl]-2-imidazolidinone;2-Imidazolidinone, 1-(3-chlorophenyl)-3-[2-(3,3-dimethyl-1-azetidinyl)ethyl]-
- CBNumber:
- CB61180095
- Molecular Formula:
- C16H22ClN3O
- Molecular Weight:
- 307.823
- MDL Number:
- MFCD00867738
- MOL File:
- 51940-78-4.mol
| FDA UNII | 3B5J9TG94X |
|---|
Zetidoline Chemical Properties,Uses,Production
Originator
MDL 308 ,Dow Chemical
Manufacturing Process
A solution of 5.0 g of 1-(m-chlorophenyl)-2-imidazolidinone in 30 ml of dimethylformamide is added at room temperature to a mixture of 1.5 g of 50% NaH (mineral oil emulsion) in 30 ml of dimethylformamide. The reaction mixture is stirred for 1 h at room temperature and then 4.5 g of 3,3-dimethyl- 1-(2-chloroethyl)azetidine are added. The mixture is stirred again at room temperature for 2 h and then it is heated for 5 h at 80°-85°C. The salts are filtered off and the solvent is removed under vacuum. The residue is taken up with 8 ml of 18% HCl and 16 ml of water and extracted with diethyl ether. The water solution is alkalinized by addition of 15% sodium carbonate and then extracted with diethyl ether. By evaporation of the organic layer a residue is obtained that is triturated in light petroleum. Yield of 1-(m- chlorophenyl)-3-[2-(3,3-dimethylazetidin-1-y1)ethyl]-2-imidazolidinone 7.25 g, melting point 84°-85°C (after recrystallization from hexane).
Therapeutic Function
Antipsychotic, Neuroleptic
Zetidoline Preparation Products And Raw materials
Zetidoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Hefei fuya biotechnology co. LTD | 18096409024 | sales02@foreversyn.com | China | 1974 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Hefei fuya biotechnology co. LTD | 58 |