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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED structure

CAS No.: 2803699-72-9

Chemical Name:: INDEX NAME NOT YET ASSIGNED

Synonyms: 113-O12B

CBNumber:: CB612037122

Molecular Formula:: C57H111N3O8S8

Molecular Weight:: 1223.01

MDL Number:

MOL File:: 2803699-72-9.mol

Last updated:2023-05-21 10:59:17

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INDEX NAME NOT YET ASSIGNED Properties

Boiling point	1025.1±65.0 °C(Predicted)
Density	1.095±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Ethanol: 10 mg/ml
pka	7.73±0.50(Predicted)

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

113-O12B is a disulfide bond-containing ionizable cationic lipidoid.1 It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. Subcutaneous administration of LNPs containing 113-O12B and encapsulating an mRNA reporter accumulate specifically in mouse lymph nodes. LNPs containing 113-O12B and encapsulating mRNA encoding ovalbumin reduce tumor growth and increase the number of tumoral CD8+ T cells, M1-like macrophages, and activated dendritic cells in an ovalbumin-expressing B16/F10 murine melanoma model.

References

1.Chen, J., Ye, Z., Huang, C., et al.Lipid nanoparticle-mediated lymph node-targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell responseProc. Natl. Acad. Sci. USA119(34)e2207841119(2022)

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 6)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Changyu Medical Technology Co. Ltd.	+86-13301875428	sales@changyuhe.com	China	297	58
Shochem(Shanghai)Co.,Ltd	+86-021-51783479 +86-13816874662	info@shochem.com	China	301	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9412	58
Shanghai Easy CDMO Co.,Ltd	021-61734564	August@easycdmo.com	China	10010	58
Shochem (Shanghai) Co.,Ltd	13611745246 13816874662	sales@shochem.com	China	447	58
Jilin Chinese Academy of Sciences-yanshen Technology	18143011203	ET-market@chemextension.com	China	41850	58

Supplier	Advantage
Shanghai Changyu Medical Technology Co. Ltd.	58
Shochem(Shanghai)Co.,Ltd	58
DC Chemicals	58
Shanghai Easy CDMO Co.,Ltd	58
Shochem (Shanghai) Co.,Ltd	58
Jilin Chinese Academy of Sciences-yanshen Technology	58

113-O12B 2803699-72-9 C57H111N3O8S8