Irinotecan hydrochloride trihydrate
- CAS No.
- 136572-09-3
- Chemical Name:
- Irinotecan hydrochloride trihydrate
- Synonyms
- Iriontecan HCL;Irinotecan HCL 3H2O;Irinotecan HydrochL;Irinotecan Trihydrate;CPT-11 HCl Trihydrate;Irinotecan Hydrochlorid;IRINOTECON HCL TRIHYDRATE;IRINOTECAN HCL TRIHYDRATE;Irinotecan HCI Trihydrate;trihydrate,(s)-hydrochlorid
- CBNumber:
- CB6122430
- Molecular Formula:
- C33H45ClN4O9
- Molecular Weight:
- 677.18
- MDL Number:
- MFCD01765731
- MOL File:
- 136572-09-3.mol
Melting point | 250-256°C (dec.) |
---|---|
Boiling point | 257°C(lit.) |
storage temp. | 2-8°C |
solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml). |
form | White solid. |
color | Yellow |
Water Solubility | Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming |
Merck | 14,5091 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months. |
CAS DataBase Reference | 136572-09-3(CAS DataBase Reference) |
FDA UNII | 042LAQ1IIS |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07,GHS08 |
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Signal word | Danger | |||||||||
Hazard statements | H302-H372 | |||||||||
Precautionary statements | P260-P264b-P270-P301+P312-P314-P330-P403-P501c | |||||||||
Risk Statements | 22 | |||||||||
Safety Statements | 20/21-22 | |||||||||
RTECS | DW1060750 | |||||||||
HS Code | 29349990 | |||||||||
Toxicity | dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |||||||||
NFPA 704 |
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Irinotecan hydrochloride trihydrate price More Price(50)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 1347609 | Irinotecan hydrochloride United States Pharmacopeia (USP) Reference Standard | 136572-09-3 | 100MG | $698 | 2024-03-01 | Buy |
TCI Chemical | I0714 | Irinotecan Hydrochloride Trihydrate >98.0%(HPLC)(T) | 136572-09-3 | 100mg | $84 | 2024-03-01 | Buy |
Alfa Aesar | J62370 | Irinotecan hydrochloride trihydrate 99% | 136572-09-3 | 100mg | $172.65 | 2024-03-01 | Buy |
Alfa Aesar | J62370 | Irinotecan hydrochloride trihydrate 99% | 136572-09-3 | 250mg | $337.65 | 2024-03-01 | Buy |
Cayman Chemical | 14180 | Irinotecan (hydrochloride hydrate) | 136572-09-3 | 100mg | $96 | 2024-03-01 | Buy |
Irinotecan hydrochloride trihydrate Chemical Properties,Uses,Production
Description
Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
Chemical Properties
White powder
Uses
Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.
Definition
ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
brand name
Camptosar (Pharmacia &Upjohn) .
Hazard
Moderately toxic by ingestion.
References
1) Kunimoto et al. (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin against murine tumors; Cancer Res., 47 5944 2) Mathijssen et al., (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan; Curr. Cancer Drug Targets, 253 5892 3) Pfizer drug insert
Irinotecan hydrochloride trihydrate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12834 | 58 |
Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-17333973358 | sales06@hbduling.cn | China | 8051 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | info@hyper-chem.com | China | 295 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9087 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2930 | 58 |
Hainan Xiyuan Chemical Technology Co., Ltd. | +86-15008981366 | 15008981366@163.com | CHINA | 9 | 58 |
View Lastest Price from Irinotecan hydrochloride trihydrate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-12-13 | Irinotecan hydrochloride trihydrate
136572-09-3
|
US $0.00 / g/Bag | 1g | 98%-102%; USP | 1000G | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-11-28 | Irinotecan hydrochloride trihydrate
136572-09-3
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | ||
2024-11-19 | Irinotecan hydrochloride trihydrate
136572-09-3
|
US $36.00-72.00 / mg | 99.79% | 10g | TargetMol Chemicals Inc. |
- Irinotecan hydrochloride trihydrate
136572-09-3
- US $0.00 / g/Bag
- 98%-102%; USP
- WUHAN FORTUNA CHEMICAL CO., LTD
- Irinotecan hydrochloride trihydrate
136572-09-3
- US $10.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
- Irinotecan hydrochloride trihydrate
136572-09-3
- US $36.00-72.00 / mg
- 99.79%
- TargetMol Chemicals Inc.