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| | Irinotecan hydrochloride trihydrate Basic information |
| Product Name: | Irinotecan hydrochloride trihydrate | | Synonyms: | Irinotecan-d10 hydrochloride trihydrate;CPT-11 HCl Trihydrate;irinotecan hydrochloride hydrate;Irinotecanhydrochloridetrihydrate(CPT-11);IRINOTECON HCL TRIHYDRATE;[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE;(S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%;Irinotecan Hydrochloride (100 mg) | | CAS: | 136572-09-3 | | MF: | C33H45ClN4O9 | | MW: | 677.18 | | EINECS: | 603-967-2 | | Product Categories: | Inhibitors;Anticancer;Anti-cancer&immunity;API | | Mol File: | 136572-09-3.mol |  |
| | Irinotecan hydrochloride trihydrate Chemical Properties |
| Melting point | 250-256°C (dec.) | | Boiling point | 257°C(lit.) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml). | | form | White solid. | | color | Yellow | | Water Solubility | Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming | | Merck | 14,5091 | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months. | | CAS DataBase Reference | 136572-09-3(CAS DataBase Reference) |
| Risk Statements | 22 | | Safety Statements | 20/21-22 | | RTECS | DW1060750 | | HS Code | 29349990 | | Toxicity | dog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. |
| | Irinotecan hydrochloride trihydrate Usage And Synthesis |
| Description | Irinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3 | | Chemical Properties | White powder | | Uses | Irinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor. | | Definition | ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine
based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. | | Brand name | Camptosar (Pharmacia &Upjohn)
. | | Hazard | Moderately toxic by ingestion. | | References | 1) Kunimoto et al. (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin against murine tumors; Cancer Res., 47 5944
2) Mathijssen et al., (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan; Curr. Cancer Drug Targets, 253 5892
3) Pfizer drug insert |
| | Irinotecan hydrochloride trihydrate Preparation Products And Raw materials |
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