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Irinotecan hydrochloride trihydrate

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Products Intro: Product Name:Irinotecan hydrochloride trihydrate
CAS:136572-09-3
Purity:99% Package:1KG;10.00;USD
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Products Intro: Product Name:Irinotecan hydrochloride trihydrate
CAS:136572-09-3
Purity:99% Package:25KG
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CAS:136572-09-3
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Products Intro: Product Name:Irinotecan hydrochloride trihydrate
CAS:136572-09-3
Purity:99%, USP Package:1KG;|5KG;|25KG
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Products Intro: Product Name:Irinotecan Hydrochloride Trihydrate
CAS:136572-09-3
Purity:98% (Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg

Irinotecan hydrochloride trihydrate manufacturers

Irinotecan hydrochloride trihydrate Basic information
Product Name:Irinotecan hydrochloride trihydrate
Synonyms:Irinotecan-d10 hydrochloride trihydrate;CPT-11 HCl Trihydrate;irinotecan hydrochloride hydrate;Irinotecanhydrochloridetrihydrate(CPT-11);IRINOTECON HCL TRIHYDRATE;[1,4'-BIPIPERIDINE]-1'-CARBOXYLIC ACID (S)-4,11-DIETHYL-3,4,12,14-TETRAHYDRO-4-HYDROXY-3,14-DIOXO-1H-PYRANO[3',4',6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL ESTER, HCL TRIHYDRATE;(S)-[1,4'-Bipiperidine]-1'-carboxylic acid 4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester hydrochloride trihydrate ,99%;Irinotecan Hydrochloride (100 mg)
CAS:136572-09-3
MF:C33H45ClN4O9
MW:677.18
EINECS:603-967-2
Product Categories:Inhibitors;Anticancer;Anti-cancer&immunity;API
Mol File:136572-09-3.mol
Irinotecan hydrochloride trihydrate Structure
Irinotecan hydrochloride trihydrate Chemical Properties
Melting point 250-256°C (dec.)
Boiling point 257°C(lit.)
storage temp. 2-8°C
solubility Soluble in DMSO (up to 50 mg/ml), in Water (up to 4 mg/ml) or in Ethanol (up to 4 mg/ml).
form White solid.
color Yellow
Water Solubility Soluble in DMSO at 100mg/ml. Soluble in water at 25mg/ml with warming
Merck 14,5091
Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol or distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference136572-09-3(CAS DataBase Reference)
Safety Information
Risk Statements 22
Safety Statements 20/21-22
RTECS DW1060750
HS Code 29349990
Toxicitydog,LD50,intravenous,40mg/kg (40mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
MSDS Information
Irinotecan hydrochloride trihydrate Usage And Synthesis
DescriptionIrinotecan (136572-09-3) is a semi-synthetic derivative of camptothecin (Cat.# 10-1041) that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38, Cat.# 10-2425), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
Chemical PropertiesWhite powder
UsesIrinotecan Hydrochloride Trihydrate is a DNA topoisomerase inhibitor.
DefinitionChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.
Brand nameCamptosar (Pharmacia &Upjohn) .
HazardModerately toxic by ingestion.
References1) Kunimoto et al. (1987) Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, a novel water-soluble derivative of camptothecin against murine tumors; Cancer Res., 47 5944 2) Mathijssen et al., (2002) Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecan; Curr. Cancer Drug Targets, 253 5892 3) Pfizer drug insert
Irinotecan hydrochloride trihydrate Preparation Products And Raw materials
Raw materialsIrinotecan hydrochloride
Tag:Irinotecan hydrochloride trihydrate(136572-09-3) Related Product Information
Irinotecan Impurity 18 (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Irinotecan hydrochloride 12-Hydroxy Irinotecan GURKHSYORGJETM-MGDILKBHSA-N Irinotecan Impurity 19 Irinotecan Impurity 24 Cisplatin 5-Fluorouracil Topotecan hydrochloride Crizotinib Oxaliplatin Olaparib Mesna Docetaxel 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride 1-benzyl-4-(piperidin-1-yl)-1,2,3,6-tetrahydropyridine [1,4'-Bipiperidine]-1'-carboxylic acid