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Amprolium

CAS No.
121-25-5
Chemical Name:
Amprolium
Synonyms
AMPROLIUM;Amprolium HCI;AMproliuM, USP;Amprolium [INN:BAN];Amprolium USP/EP/BP;AMPROLIUM USP 26, BPV 98;Venlafaxine Impurity 1-d6;amprolium/amprolium hydrochloride;(1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID.;1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride
CBNumber:
CB6127743
Molecular Formula:
C14H19N4.Cl
Molecular Weight:
278.79
MDL Number:
MFCD00072061
MOL File:
121-25-5.mol
Last updated:2024-12-18 14:08:57

Amprolium Properties

Melting point 246-248 °C (decomp)
storage temp. 0-6°C
solubility Soluble in DMSO
color Crystals from methanol + ethanol
Stability Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
InChI InChI=1S/C14H19N4.ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);1H/q+1;/p-1
InChIKey LCTXBFGHZLGBNU-UHFFFAOYSA-M
SMILES C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.[Cl-]
CAS DataBase Reference 121-25-5(CAS DataBase Reference)
FDA 21 CFR 556.50; 558.55
FDA UNII 71M75T660B
EPA Substance Registry System Amprolium (121-25-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

Amprolium price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2345 Amprolium Pharmaceutical Secondary Standard; Certified Reference Material 121-25-5 500MG $200 2024-03-01 Buy
TRC A634413 Amprolium 121-25-5 2.5mg $45 2021-12-16 Buy
TRC A634413 Amprolium 121-25-5 5mg $60 2021-12-16 Buy
Medical Isotopes, Inc. 18478 Amprolium 121-25-5 25mg $1500 2021-12-16 Buy
Crysdot CD31004266 Amprolium 98+% 121-25-5 100mg $50 2021-12-16 Buy
Product number Packaging Price Buy
PHR2345 500MG $200 Buy
A634413 2.5mg $45 Buy
A634413 5mg $60 Buy
18478 25mg $1500 Buy
CD31004266 100mg $50 Buy

Amprolium Chemical Properties,Uses,Production

Description

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Chemical Properties

solid

Originator

Neoprol ,SIMB

Uses

Coccidiostat (for poultry).

Uses

Amprolium is an oral coccidiostat, a thiamine analogue, which is used for the prevention and treatment of intestinal coccidiosis . It is used as a feed additive for livestock, sometimes administered in the food or drinking water of puppies and kittens, and in chickens and calves.

Definition

ChEBI: An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.

Manufacturing Process

1.9 grams of p-toluene sulfonyl chloride was added gradually with shaking to a cooled (0-5°C) solution of 1.67 grams of 2-n-propyl-4-amino-5-hydroxymethyl pyrimidine in 10 ml of 2-methylpyridine. The reaction mixture, after standing three hours in an ice bath, and 15 hours at room temperature, was evaporated to dryness in vacuo. The residue was dissolved in 20 ml of water, acidified with hydrochloric acid and poured over a column of Amberlite IRA- 400 ion exchange resin on the chloride cycle. The eluate was evaporated to dryness to give a residue of 1-(2-n-propyl-4-amino-5-pyrimidylmethyl)-2- methyl pyridinium chloride hydrochloride. On recrystallization from a methanol-ethanol mixture, the quaternary had melting point 246°C (dec.).

brand name

Amprol [Veterinary] (Merial); Amprovine [Veterinary] (Merial); Corid [Veterinary] (Merial).

Therapeutic Function

Coccidiostatic

Contact allergens

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Side effects

Amprolium is considered one of the safest anticoccidial medications, and adverse reactions such as anorexia or diarrhoea may occur with high doses and prolonged use. Thiamine deficiency can cause central nervous system (CNS) symptoms, but can be reversed with the addition of thiamine to the diet. However, thiamine supplementation may affect the efficacy of the drug.

Safety Profile

When heated to decomposition emits toxic fumes of Cl-.

Amprolium Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 175)Suppliers
Supplier Tel Email Country ProdList Advantage
shandong perfect biotechnology co.ltd
+86-53169958659 +86-13153181156 sales@sdperfect.com China 294 58
Hebei Weibang Biotechnology Co., Ltd
+8615531157085 abby@weibangbio.com China 8807 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12834 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22963 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58

View Lastest Price from Amprolium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Amprolium pictures 2024-11-19 Amprolium
121-25-5
US $1.00 / kg 1kg 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
amprolium hydrochloride pictures 2024-11-19 amprolium hydrochloride
121-25-5
US $0.00 / KG 1KG 98% HPLC 5 ton shandong perfect biotechnology co.ltd
Amprolium pictures 2024-08-15 Amprolium
121-25-5
US $120.00 / kg 1kg 0.99 1000000 Hebei Fengjia New Material Co., Ltd
  • Amprolium pictures
  • Amprolium
    121-25-5
  • US $1.00 / kg
  • 99%
  • Hebei Weibang Biotechnology Co., Ltd
  • Amprolium pictures
  • Amprolium
    121-25-5
  • US $120.00 / kg
  • 0.99
  • Hebei Fengjia New Material Co., Ltd
AMPROLIUM 1-[[4-Amino-2-propyl-5-pyrimidinyl] methyl]-2-picolinium chloride hydrochloride 1-[2-Propyl-4-amino-5-pyrimidylmethyl]-2-methylpyridinium chloride hydrochloride Pyridinium, 1-(4-amino-2-propyl-5-pyrimidinyl)methyl-2-methyl-, chloride AMPROLIUM USP 26, BPV 98 (1-(4-AMINO-2-PROPYL-5-PYRIMIDINYL)-METHYL)-2-METHYLPYRID. 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride Amprolium [INN:BAN] AMproliuM, USP [5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-yl]amine chloride 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propyl-pyrimidin-4-amine chloride 5-[(2-methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride (1R,2S,4aS,8aS)-1-(hydroxymethyl)-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydronaphthalene-1,2-diol Amprolium USP/EP/BP 1-((4-Amino-2-propylpyrimidin-5-yl)methyl)-2-methylpyridin-1-ium chloride amprolium/amprolium hydrochloride Amprolium HCI Venlafaxine Impurity 1-d6 121-25-5 C14H19CIN4HCl C14H19ClN4 APIs API's