Amprolium Hydrochloride
- CAS No.
- 137-88-2
- Chemical Name:
- Amprolium Hydrochloride
- Synonyms
- AMPROLIUM HCL;Amprolio;2-picolinium,1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-,chloride,monohydroc;amprol;amprol25;mepyrium;Amprovine;Ampomycin;CB2101848;thiacoccid
- CBNumber:
- CB2101848
- Molecular Formula:
- C14H20Cl2N4
- Molecular Weight:
- 315.24
- MDL Number:
- MFCD00078831
- MOL File:
- 137-88-2.mol
- MSDS File:
- SDS
| Melting point | 239.0 to 243.0 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Powder |
| color | White to Off-white |
| BRN | 4118699 |
| InChI | InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1 |
| InChIKey | PJBQYZZKGNOKNJ-UHFFFAOYSA-M |
| SMILES | C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.Cl.[Cl-] |
| CAS DataBase Reference | 137-88-2(CAS DataBase Reference) |
| FDA UNII | 95CO6N199Q |
| EPA Substance Registry System | Amprolium hydrochloride (137-88-2) |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P272-P280-P284-P302+P352-P333+P313 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | TJ7565000 |
| HS Code | 29335995 |
Amprolium Hydrochloride price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 31592 | Amprolium hydrochloride cationic | 137-88-2 | 250mg | $52.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1034002 | Amprolium United States Pharmacopeia (USP) Reference Standard | 137-88-2 | 200mg | $261.6 | 2024-03-01 | Buy |
| TCI Chemical | A2572 | Amprolium Hydrochloride [for Biochemical Research] >98.0%(HPLC)(T) | 137-88-2 | 5g | $25 | 2024-03-01 | Buy |
| TCI Chemical | A2572 | Amprolium Hydrochloride [for Biochemical Research] >98.0%(HPLC)(T) | 137-88-2 | 25g | $70 | 2024-03-01 | Buy |
| Alfa Aesar | J64782 | 1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium chloride | 137-88-2 | 25g | $90.2 | 2023-06-20 | Buy |
Amprolium Hydrochloride Chemical Properties,Uses,Production
Description
Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.
Chemical Properties
Crystalline powder
Uses
1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity.
Uses
Thiamine analog coccidiostat.
Uses
Coccidiostatic;Thiamine transport inhibitor
Definition
MeSH: Amprolium Hydrochloride is a veterinary coccidiostat that interferes with thiamine metabolism.
Contact allergens
Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.
Veterinary Drugs and Treatments
Amprolium has good activity against Eimeria tenella and E. acervulina
in poultry and can be used as a therapeutic agent for these
organisms. It only has marginal activity or weak activity
against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in
combination with other agents (e.g., ethopabate) to improve control
against those organisms.
In cattle, amprolium has approval for the treatment and prevention
of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the
control of coccidiosis, although there are no approved products in
the USA for these species.
Amprolium Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-17396673057 | linda@tnjone.com | China | 1143 | 58 |
| Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 | sales@suikangpharm.com | China | 311 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | angelia@hbmojin.com | China | 750 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Hebei Yiduo Import and Export Co., Ltd. | joycedemei1505@outlook.com | China | 204 | 58 | |
| Hebei Junhua Import and Export Co., LTD | +86-18503288844 +86-18503288844 | junhua1@hb-junhua.com | China | 978 | 58 |
Related Qustion
- Q:Does Amprolium Hydrochloride have any effect on human health?
- A:Yes, it can cause adverse reactions such as contact dermatitis and asthma. Adverse reactions of anorexia or diarrhoea are rare....
- Dec 7，2023
View Lastest Price from Amprolium Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-26 | Amprolium Hydrochloride
137-88-2
|
US $0.00-0.00 / KG | 1KG | 99% | 1 ton/year | Forest chemical technology | |
 |
2025-04-25 | Amprolium HCl
137-88-2
|
US $150.00 / kg | 1kg | 99% | 500kg | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2025-04-25 | Amprolium HCl
137-88-2
|
US $150.00 / kg | 1kg | 99% | 500kg | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- Amprolium Hydrochloride
137-88-2
- US $0.00-0.00 / KG
- 99%
- Forest chemical technology
-
- Amprolium HCl
137-88-2
- US $150.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- Amprolium HCl
137-88-2
- US $150.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd