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4-Amino-5-aminomethyl-2-methylpyrimidine

4-Amino-5-aminomethyl-2-methylpyrimidine structure

CAS No.: 95-02-3

Chemical Name:: 4-Amino-5-aminomethyl-2-methylpyrimidine

Synonyms: Grewe DiaMine;2-methyl-4-amino-5-aminomethylpyrimidine;4-amino-2-methylpyrimidine-5-methylamine;Thiamine Impurity 16;Thiamine Impurity 48;Vitamin B1 Impurity 9;Diazinon Impurity 6 (Diazoxon);Thiamine /Vitamin B1 Impurity 19;2-Methyl-4-aminopyrimidine-5-methanamine;5-Aminomethyl-2-methyl-4-pyrimidineamine

CBNumber:: CB9757404

Molecular Formula:: C6H10N4

Molecular Weight:: 138.17

MDL Number:: MFCD00058194

MOL File:: 95-02-3.mol

Last updated:2024-08-14 19:04:07

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4-Amino-5-aminomethyl-2-methylpyrimidine Properties

Melting point	270-272°C
Boiling point	121-125 °C
Density	1.207
vapor pressure	0.012-0.019Pa at 20-25℃
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
form	Solid
pka	7.70±0.29(Predicted)
color	Off-White to Beige
PH	10.65 at 20℃ and 10g/L
InChI	InChI=1S/C6H10N4/c1-4-9-3-5(2-7)6(8)10-4/h3H,2,7H2,1H3,(H2,8,9,10)
InChIKey	OZOHTVFCSKFMLL-UHFFFAOYSA-N
SMILES	C1(C)=NC=C(CN)C(N)=N1
LogP	-2.27 at 20℃ and pH7
Surface tension	72.77mN/m at 1g/L and 20℃
FDA UNII	EU1UNR0P28

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P305+P351+P338-P310
HS Code	2933599590

4-Amino-5-aminomethyl-2-methylpyrimidine price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2633	4-Amino-5-aminomethyl-2-methylpyrimidine	95-02-3	200MG	$211	2024-03-01	Buy
TRC	A581865	4-Amino-5-aminomethyl-2-methylpyrimidine	95-02-3	1g	$440	2021-12-16	Buy
Usbiological	A1374-66	4-Amino-5-aminomethyl-2-methylpyrimidine, Dihydrochloride	95-02-3	500mg	$460	2021-12-16	Buy
Biosynth Carbosynth	FA17606	4-Amino-5-aminomethyl-2-methylpyrimidine	95-02-3	2g	$520	2021-12-16	Buy
Medical Isotopes, Inc.	6342	4-Amino-5-aminomethyl-2-methylpyrimidine	95-02-3	1g	$790	2021-12-16	Buy

Product number	Packaging	Price	Buy
A2633	200MG	$211	Buy
A581865	1g	$440	Buy
A1374-66	500mg	$460	Buy
FA17606	2g	$520	Buy
6342	1g	$790	Buy

4-Amino-5-aminomethyl-2-methylpyrimidine Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

Substrate for TenA enzyme in the thiamin salvage pathway

Definition

ChEBI: An aminopyrimidine compound having its amino substituent at the 4-position together with methyl and aminomethyl substituents at the 2- and 5-positions respectively.

Synthesis

In an autoclave, the mixture of 4-Amino-5-aminomethyl-2-methylpyrimidine (2.0 kg, 15 mol), modified Raney nickel (wet weight 300 g), and saturated methanol solution of ammonia (20 L) was heated to 100 ℃ and stirred for 5 h at this temperature under 4 MPa hydrogen pressure. Then, the mixture was cooled to room temperature and filtered; 4-Amino-5-aminomethyl-2-methyl pyrimidine was obtained as a white solid (2.0 kg, 98%) by concentrating the filtrate[1].

References

[1] Lei Zhao, Fen-Er Chen, Xiao-Dong Ma. “Development of Two Scalable Syntheses of 4-Amino-5-aminomethyl-2-methylpyrimidine: Key Intermediate for Vitamin B1.” Organic Process Research & Development 16 1 (2011): 57–60.

4-Amino-5-aminomethyl-2-methylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

THIAMINE HYDROCHLORIDE

4-Amino-5-aminomethyl-2-methylpyrimidine Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changzhou uniringchem Co., Ltd.	+undefined13585446801	sales@uniringchem.com	China	68	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	+8618795957998	karmelhk@126.com	CHINA	2886	58
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; +8619817745290	bd@blocksynth.com	China	5659	58

Supplier	Advantage
Changzhou uniringchem Co., Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
KARMEL TECHNOLOGY (HK) CO.,LIMITED	58
Blocksynth Pharmaceutical Technology Co.,Ltd	58

View Lastest Price from 4-Amino-5-aminomethyl-2-methylpyrimidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-08-14	4-Amino-5-aminomethyl-2-methylpyrimidine 95-02-3	US $0.00-0.00 / KG	1KG	99.0%	1000KG	Shaanxi Dideu Medichem Co. Ltd
	2021-12-14	4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE 95-02-3	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

4-Amino-5-aminomethyl-2-methylpyrimidine
95-02-3
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE
95-02-3
US $1.10 / g
99.00%
Dideu Industries Group Limited

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4-Amino-2-methyl-5-pyrimidinemethanamine,dihydrochlorine 2-Methyl-4-aminopyrimidine-5-methanamine 2-Methyl-5-(aminomethyl)-4-pyrimidinamine 5-Aminomethyl-2-methyl-4-pyrimidineamine (4-amino-2-methyl-pyrimidin-5-yl)methylamine 4-AMINO-2-METHYL-5-PYRIMIDINEMETHANAMINE, DIHYDROCHLORIDE 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE 5-Pyrimidinemethanamine, 4-amino-2-methyl- (9CI) 5-(Aminomethyl)-4-amino-2-methylpyrimidine 5-PyriMidineMethanaMine,4-aMino-2-Methyl- 4-Amino-5-aminomethyl-2-methylpyrimidine hydrochloride 2-methyl-4-amino-5-aminomethylpyrimidine 2HCl Thiamine Impurity 16 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE, DIHYDROCHLORIDE ISO 9001：2015 REACH 2-methyl-4-amino-5-aminomethylpyrimidine Grewe DiaMine 4-amino-2-methylpyrimidine-5-methylamine Thiamine Impurity 48 4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE Diazinon Impurity 6 (Diazoxon) Vitamin B1 Impurity 9 Thiamine /Vitamin B1 Impurity 19 95-02-3 C6H12Cl2N4 C6H10N42HCl Bases & Related Reagents Nucleotides Amines Aromatics Enzyme substrates Heterocycles Nucleotides and Nucleosides Heterocycle-Pyrimidine series PYRIMIDINE