2-BROMOHEXADECANOIC ACID
- CAS No.
- 18263-25-7
- Chemical Name:
- 2-BROMOHEXADECANOIC ACID
- Synonyms
- 2-bromopalmitate;2-BROMOPALMITIC ACID;Hexadecanoic acid, 2-bromo-;ALPHA-BROMOPALMITATE;α-Bromopalmitic acid;A-BROMOPALMITIC ACID;Bromohexadecanoicacid;2-bromo-hexadecanoicaci;2-BROMOHEXADECANOIC ACID;2-Bromohexadecanoicacid97%
- CBNumber:
- CB6143327
- Molecular Formula:
- C16H31BrO2
- Molecular Weight:
- 335.32
- MDL Number:
- MFCD00004215
- MOL File:
- 18263-25-7.mol
- MSDS File:
- SDS
Melting point | 52-54 °C |
---|---|
Boiling point | 403.4±18.0 °C(Predicted) |
Density | 1.1985 (rough estimate) |
refractive index | 1.4650 (estimate) |
Flash point | 113 °C |
storage temp. | RT |
solubility | methanol: soluble1g/10 mL, clear, colorless |
form | solid |
pka | 2.97±0.21(Predicted) |
color | White |
BRN | 1726517 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
CAS DataBase Reference | 18263-25-7(CAS DataBase Reference) |
FDA UNII | 7EI4G5X28Z |
EPA Substance Registry System | Hexadecanoic acid, 2-bromo- (18263-25-7) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 2915907098 | |||||||||
NFPA 704 |
|
2-BROMOHEXADECANOIC ACID price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 238422 | 2-Bromohexadecanoic acid ~97% | 18263-25-7 | 10g | $51.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 21604 | 2-Bromohexadecanoic acid ≥99.0% (GC) | 18263-25-7 | 1g | $102 | 2024-03-01 | Buy |
Sigma-Aldrich | 238422 | 2-Bromohexadecanoic acid ~97% | 18263-25-7 | 50g | $197 | 2024-03-01 | Buy |
SynQuest Laboratories | 2121-9-00 | 2-Bromohexadecanoic acid | 18263-25-7 | 50g | $221 | 2021-12-16 | Buy |
Biorbyt Ltd | orb546166 | 2-bromopalmitic acid >98% | 18263-25-7 | 2g | $244.8 | 2021-12-16 | Buy |
2-BROMOHEXADECANOIC ACID Chemical Properties,Uses,Production
Description
2-Bromopalmitic acid (18263-25-7) inhibits?protein S-palmitoylation.1 Blocks palmitic acid-induced increase in cAMP levels in human primary melanocytes expressing the melanocortin-1 receptor which undergoes an essential palmitoylation as a prerequisite for receptor signaling.2
Chemical Properties
WHITE CRYSTALLINE POWDER
Uses
2-Bromopalmitic Acid is used in preparation of substituted purines and their analogs for inhibiting the expression of a pattern recognition receptor.
Definition
ChEBI: A bromo fatty acid that is hexadecanoic (palmitic) acid carrying a single bromo substituent at position 2.
General Description
PPARδ (peroxisome proliferator-activated receptor, delta isoform) acts as a transcription factor for gene expression as well as playing a role in lipid metabolism regulation; activity of this receptor is ligand-regulated. 2-Bromohexadecanoic acid is a metabolically stable analoge of the fatty acid palmitic acid that has been shown to be a natural ligand for the PPARδ receptor. 2-Bromohexadecanoic acid has also been used in studies of fatty acid oxidation, palmitoylation, and glucose uptake.
Biochem/physiol Actions
2-Bromohexadecanoic acid is a PPARδ agonist. It has also been shown to inhibit fatty acid oxidation, inhibit DHHC-mediated palmitoylation, and promote glucose uptake in rat cardiac cells and the insulin-sensitive murine fibroblast line A31-IS.
Purification Methods
Recrystallise the acid from pet ether (b 60-80o, charcoal) and finally from EtOH. The ethyl ester has b 177-178o/2mm, d28 1.0484, n D 1.4560. [IR: Sweet & Estes J Org Chem 21 1426 1956, Beilstein 2 IV 1184.]
References
1) Tsukamoto et al. (2013), Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells; PLoS One, 8(9) e75831 2) Chen et al. (2017), Palmitoylation-dependent activation of MC1R prevents melanomagenesis; Nature, 549 399
2-BROMOHEXADECANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Apeloa production Co.,Limited | +8619933239880 | admin@apcl.com.cn | China | 853 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13214 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615350571055 | Sibel@weibangbio.com | China | 5341 | 58 |
View Lastest Price from 2-BROMOHEXADECANOIC ACID manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2024-08-23 | 2-bromohexadecanoic acid
18263-25-7
|
US $1.00 / g | 1g | 0.98 | 1000 | Apeloa production Co.,Limited |
-
- 2-bromohexadecanoic acid
18263-25-7
- US $1.00 / g
- 0.98
- Apeloa production Co.,Limited
18263-25-7(2-BROMOHEXADECANOIC ACID)Related Search:
1of3