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5-Chloro-1-methyl-4-nitroimidazole

5-Chloro-1-methyl-4-nitroimidazole structure

CAS No.: 4897-25-0

Chemical Name:: 5-Chloro-1-methyl-4-nitroimidazole

Synonyms: 5-CHLORO-1-METHYL-4-NITRO-1H-IMIDAZOLE;CMNI;pcmni;NSC-7852;S-50154-9;A(S50154-9);AZATHIOPRINUM;TIMTEC-BB SBB003949;Azathioprine Impurity 9;Azathioprine EP Impurity C

CBNumber:: CB6151649

Molecular Formula:: C4H4ClN3O2

Molecular Weight:: 161.55

MDL Number:: MFCD00233664

MOL File:: 4897-25-0.mol

MSDS File:: SDS

Last updated:2024-08-08 18:06:34

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5-Chloro-1-methyl-4-nitroimidazole Properties

Melting point	148-150 °C (lit.)
Boiling point	362.3±22.0 °C(Predicted)
Density	1.9518 (rough estimate)
refractive index	1.5500 (estimate)
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	-1.37±0.61(Predicted)
form	Powder
color	White
InChIKey	OSJUNMSWBBOTQU-UHFFFAOYSA-N
CAS DataBase Reference	4897-25-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	P917JW98BD
NIST Chemistry Reference	1H-imidazole, 5-chloro-1-methyl-4-nitro-(4897-25-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338-P280a-P304+P340-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

RTECS

NI4397100

HazardClass

IRRITANT

HS Code

29332900

NFPA 704

	1
2		0

5-Chloro-1-methyl-4-nitroimidazole price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	367532	5-Chloro-1-methyl-4-nitroimidazole 98%	4897-25-0	5g	$138	2024-03-01	Buy
TCI Chemical	C1646	5-Chloro-1-methyl-4-nitroimidazole >98.0%(N)	4897-25-0	5g	$84	2024-03-01	Buy
Alfa Aesar	H61824	5-Chloro-1-methyl-4-nitroimidazole, 95%	4897-25-0	1g	$33.9	2023-06-20	Buy
Alfa Aesar	H61824	5-Chloro-1-methyl-4-nitroimidazole, 95%	4897-25-0	5g	$115	2023-06-20	Buy
TRC	C369270	5-Chloro-1-methyl-4-nitroimidazole	4897-25-0	5g	$120	2021-12-16	Buy

Product number	Packaging	Price	Buy
367532	5g	$138	Buy
C1646	5g	$84	Buy
H61824	1g	$33.9	Buy
H61824	5g	$115	Buy
C369270	5g	$120	Buy

5-Chloro-1-methyl-4-nitroimidazole Chemical Properties,Uses,Production

Description

5-Chloro-1-methyl-4-nitroimidazole is an imidazole derivative. It is useful in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells. It can also be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine) palladium (II), K2CO3 and tetrabutylammonium bromide.

References

http://www.sigmaaldrich.com/catalog/product/aldrich/367532?lang=en&region=US
Watts, M. E., et al. "Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole." Int J Radiat Biol Relat Stud Phys Chem Med 38.6(1980):673-675.
Saadeh, H. A, I. M. Mosleh, and M. M. Elabadelah. "New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles. "Molecules 14.8(2009):2758-67.

Description

5-Chloro-1-methyl-4-nitroimidazole is an intermediate in azathioprine synthesis, also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross reactivity is possible with imidazoles tioconazole, and econazole.

Chemical Properties

White Solid

Uses

5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K₂CO₃ and tetrabutylammonium bromide.

General Description

5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.

Contact allergens

This intermediate in azathioprine synthesis is also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross-reactivity is possible with imidazoles tioconazole and econazole.

5-Chloro-1-methyl-4-nitroimidazole Preparation Products And Raw materials

Raw materials

Glass-lined reaction pot Phosphorus oxychloride Phosphorus pentachloride N,N'-Dimethyloxamide 5-Chloro-1-methylimidazole

Potassium nitrate

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Preparation Products

Azathioprine 1H-Imidazol-5-amine,1-methyl-4-nitro-(9CI)

5-Chloro-1-methyl-4-nitroimidazole Suppliers

Global( 297)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-18192627656	1059@dideu.com	China	3003	58
airuikechemical co., ltd.	+86-18353166132 +86-18353166132	sales02@airuikechemical.com	China	983	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10311	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
airuikechemical co., ltd.	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Standardpharm Co. Ltd.	58
Chongqing Chemdad Co., Ltd	58

View Lastest Price from 5-Chloro-1-methyl-4-nitroimidazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-08-08	5-Chloro-1-methyl-4-nitroimidazole 4897-25-0	US $1.00-2.10 / KG	1KG	99%	20000KG	Shaanxi Dideu Medichem Co. Ltd
2022-09-30	5-Chloro-1-methyl-4-nitroimidazole 4897-25-0	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2019-12-23	5-Chloro-1-methyl-4-nitroimidazole 4897-25-0	US $0.00 / g	1g	95%min	20kg/month	Nanjing jinheyou Trading Co., Ltd.

5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
US $1.00-2.10 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
US $0.00 / g
95%min
Nanjing jinheyou Trading Co., Ltd.

5-Chloro-1-methyl-4-nitroimidazole Spectrum

5-Chloro-1-methyl-4-nitroimidazole(4897-25-0)MS 5-Chloro-1-methyl-4-nitroimidazole(4897-25-0)IR1 5-Chloro-1-methyl-4-nitroimidazole(4897-25-0)IR2

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5-chloro-1-methyl-4-nitroimidazole Solution, 100ppm 5-Chloro-1-methyl-4-nitroimidazole≥ 99% (HPLC) 5-chloro-1-methyl-4-nitro-imidazol A(S50154-9) Imidazole, 5-chloro-1-methyl-4-nitro- pcmni TIMTEC-BB SBB003949 1-METHYL-5-CHLORO-4-NITRO IMIDAZOLE 1-METHYL-4-NITRO-5-CHLORO IMIDAZOLE AZATHIOPRINUM 5-CHLORO-1-METHYL-4-NITROIMIDAZOLE 5-Chloro-1-Methyl-4-NitroImidazole(ForAzathiopurine) 5-CHLORO-1-METHYL-4-NITROIMIDAZOLE (AZATHIOPRINUM) 1-Methyl-4-Nitro-5-Chloroimida 1H-Imidazole, 5-chloro-1-methyl-4-nitro- S-50154-9 1-Methyl-5-chloro-4-nitro-1H-imidazole CMNI NSC-7852 5-Chloro-1-methyl-4-nitroimidazole,98% Azathioprine EP Impurity C Azathioprine Impurity Ⅰ: 5-Chloro-1-methyl-4-nitroimidazole Azathioprine Impurity 3（Azathioprine EP Impurity C） 5-Chloro-1-methyl-4-nitroimidazole > Azathioprine Impurity 9 Azathioprine BP Impurity C 5-Chloro-1-methyl-4-nitroimidazole Solution in Methanol, 100μg/mL Azathioprine Impurity Ⅰ: 5-Chloro-1-methyl-4-nitroimidazole 5-CHLORO-1-METHYL-4-NITRO-1H-IMIDAZOLE 5-Chloro-1-methyl-4-nitroimidazole (Azathioprine Impurity) 4897-25-0 C4H4ClN3O2 Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Imidazoles Heterocycles Halogenated Heterocycles Heterocyclic Building Blocks Imidazoles ImidazolesBuilding Blocks Building Blocks Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Heterocyclic Compounds Imidaxoles