5-Chloro-1-methyl-4-nitroimidazole
- CAS No.
- 4897-25-0
- Chemical Name:
- 5-Chloro-1-methyl-4-nitroimidazole
- Synonyms
- 5-CHLORO-1-METHYL-4-NITRO-1H-IMIDAZOLE;CMNI;pcmni;NSC-7852;S-50154-9;A(S50154-9);AZATHIOPRINUM;TIMTEC-BB SBB003949;Azathioprine Impurity 9;Azathioprine EP Impurity C
- CBNumber:
- CB6151649
- Molecular Formula:
- C4H4ClN3O2
- Molecular Weight:
- 161.55
- MDL Number:
- MFCD00233664
- MOL File:
- 4897-25-0.mol
- MSDS File:
- SDS
Melting point | 148-150 °C (lit.) |
---|---|
Boiling point | 362.3±22.0 °C(Predicted) |
Density | 1.9518 (rough estimate) |
refractive index | 1.5500 (estimate) |
storage temp. | Inert atmosphere,2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
pka | -1.37±0.61(Predicted) |
form | Powder |
color | White |
InChIKey | OSJUNMSWBBOTQU-UHFFFAOYSA-N |
CAS DataBase Reference | 4897-25-0(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | P917JW98BD |
NIST Chemistry Reference | 1H-imidazole, 5-chloro-1-methyl-4-nitro-(4897-25-0) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338-P280a-P304+P340-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | NI4397100 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29332900 | |||||||||
NFPA 704 |
|
5-Chloro-1-methyl-4-nitroimidazole price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 367532 | 5-Chloro-1-methyl-4-nitroimidazole 98% | 4897-25-0 | 5g | $138 | 2024-03-01 | Buy |
TCI Chemical | C1646 | 5-Chloro-1-methyl-4-nitroimidazole >98.0%(N) | 4897-25-0 | 5g | $84 | 2024-03-01 | Buy |
Alfa Aesar | H61824 | 5-Chloro-1-methyl-4-nitroimidazole, 95% | 4897-25-0 | 1g | $33.9 | 2023-06-20 | Buy |
Alfa Aesar | H61824 | 5-Chloro-1-methyl-4-nitroimidazole, 95% | 4897-25-0 | 5g | $115 | 2023-06-20 | Buy |
TRC | C369270 | 5-Chloro-1-methyl-4-nitroimidazole | 4897-25-0 | 5g | $120 | 2021-12-16 | Buy |
5-Chloro-1-methyl-4-nitroimidazole Chemical Properties,Uses,Production
Description
5-Chloro-1-methyl-4-nitroimidazole is an imidazole derivative. It is useful in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells. It can also be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine) palladium (II), K2CO3 and tetrabutylammonium bromide.
References
http://www.sigmaaldrich.com/catalog/product/aldrich/367532?lang=en®ion=US
Watts, M. E., et al. "Rapid-mix studies on the anomalous radiosensitization of mammalian cells by 5-chloro-1-methyl-4-nitromidazole." Int J Radiat Biol Relat Stud Phys Chem Med 38.6(1980):673-675.
Saadeh, H. A, I. M. Mosleh, and M. M. Elabadelah. "New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles. "Molecules 14.8(2009):2758-67.
Description
5-Chloro-1-methyl-4-nitroimidazole is an intermediate in azathioprine synthesis, also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross reactivity is possible with imidazoles tioconazole, and econazole.
Chemical Properties
White Solid
Uses
5-Chloro-1-methyl-4-nitroimidazole (CMNI) is suitable for use in the rapid mix experiments to investigate the mechanism of anomalous radiosensitization of mammalian cells by CMNI. It may be used in the synthesis of 5-aryl-1-methyl-4-nitroimidazoles, via Suzuki coupling with arylboronic acids, catalyzed by dichlorobis-(triphenylphosphine)palladium(II), K2CO3 and tetrabutylammonium bromide.
General Description
5-Chloro-1-methyl-4-nitroimidazole is an 4-nitroimidazole derivative.
Contact allergens
This intermediate in azathioprine synthesis is also present in the end product. It induced contact dermatitis in a man working on azathioprine synthesis. Cross-reactivity is possible with imidazoles tioconazole and econazole.
5-Chloro-1-methyl-4-nitroimidazole Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 2747 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 983 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29897 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 925 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10312 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from 5-Chloro-1-methyl-4-nitroimidazole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2024-08-08 | 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
|
US $1.00-2.10 / KG | 1KG | 99% | 20000KG | Shaanxi Dideu Medichem Co. Ltd | |
![]() |
2024-04-08 | 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
![]() |
2022-09-30 | 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
- US $1.00-2.10 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- 5-Chloro-1-methyl-4-nitroimidazole
4897-25-0
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.