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NODULARIN
- CAS No.
- 118399-22-7
- Chemical Name:
- NODULARIN
- Synonyms
- NODULARIN;Nodularin-R solution;Nodularin solution ;IXBQSRWSVIBXNC-HSKGSTCASA-N;Nodularin, Nodularia spumigena;yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl);1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide;1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE;tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth
- CBNumber:
- CB6225379
- Molecular Formula:
- C41H60N8O10
- Molecular Weight:
- 824.96
- MDL Number:
- MFCD16659855
- MOL File:
- 118399-22-7.mol
Last updated:2023-06-08 09:01:56
| Density | 1.29±0.1 g/cm3(Predicted) |
|---|---|
| Flash point | 11℃ |
| storage temp. | −20°C |
| solubility | methanol: 2 mg/mL Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months. |
| form | Dry residue containing traces of monobasic potassium phosphate. |
| pka | 3.39±0.70(Predicted) |
| FDA UNII | 0979BIK2QU |
| IARC | 3 (Vol. 94) 2010 |
| EPA Substance Registry System | Nodularin (118399-22-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H315-H317-H319-H335 | |||||||||
| Precautionary statements | P260-P262-P280-P302+P352+P310-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T,F,T+ | |||||||||
| Risk Statements | 23/24/25-38-39/23/24/25-11-43-36/37/38-26/27/28 | |||||||||
| Safety Statements | 36/37-45-16-7-36/37/39-26 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GU2294250 | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,60ug/kg (0.06mg/kg),Chemical Research in Toxicology. Vol. 6, Pg. 151, 1993. | |||||||||
| NFPA 704 |
|
NODULARIN price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N5148 | Nodularin cyanotoxin | 118399-22-7 | 250μg | $638 | 2024-03-01 | Buy |
| Sigma-Aldrich | 32539 | Nodularin solution 10μg/mL in methanol, analytical standard | 118399-22-7 | 1ml | $590 | 2024-03-01 | Buy |
| Cayman Chemical | 10007190 | Nodularin ≥95% | 118399-22-7 | 100μg | $138 | 2024-03-01 | Buy |
| Usbiological | 170023 | Nodularin | 118399-22-7 | 100ug | $325 | 2021-12-16 | Buy |
| TRC | N634260 | Nodularin | 118399-22-7 | 1mg | $1320 | 2021-12-16 | Buy |
NODULARIN Chemical Properties,Uses,Production
Description
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.
Uses
Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.
Definition
Toxin produced by blue green algae.
NODULARIN Preparation Products And Raw materials
Raw materials
Preparation Products
NODULARIN Suppliers
Global( 45)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10011 | 58 |
| Naturewill Biotechnology Co., Ltd. | 18113192475 18113192475 | 3157321941@qq.com | China | 5000 | 58 |
| Guangzhou Yaoguang Technology Co., Ltd. | 13020159086 | yangjue@ygfuture.com | China | 490 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
118399-22-7(NODULARIN)Related Search:
Tris(2,4-pentanedionato)chroMiuM(III)
PHENYLSELENOL
METHYL ISOCYANOACETATE
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
Tosylmethyl isocyanide
1of4
tyl-l-arginyl-(2s,3s,4e,6e,8s,9s)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimeth
yl-10-phenyl-3-aminodecanoyl-d-gamma-glutamyl)
NODULARIN
1,4,8,11,15-PENTAAZACYCLONONADECANE, CYCLIC PEPTIDE DERIVATIVE
Nodularin, Nodularia spumigena
1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl)
Cyclo(L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-gamma-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-beta-aspartyl)
Nodularin,1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide
Nodularin-R solution
Nodularin solution
cyclo((z)-2,3-didehydro-n-methyl-2-aminobutanoyl-erythro-3-methyl-d-beta-aspar
IXBQSRWSVIBXNC-HSKGSTCASA-N
Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl]
118399-22-7
C41H60N8O10
Application Index
Biochemicals and Reagents
BioChemical
Cell Signaling Enzymes
Cyanobacterial Toxins
Enzymes, Inhibitors, and Substrates
Natural Products