Coluracetam
- CAS No.
- 135463-81-9
- Chemical Name:
- Coluracetam
- Synonyms
- BCI-540;COLURACETAM;Colurac tam;MKC-231;BCI-540;Coluracetam, >=99%;Coluracetam, MKC-231;COLURACETAM USP/EP/BP;top quality Coluracetam;MKC-231; MKC231; MKC 231;CAS135463-81-9 COLURACETAM
- CBNumber:
- CB62446491
- Molecular Formula:
- C19H23N3O3
- Molecular Weight:
- 341.4
- MDL Number:
- MFCD00901416
- MOL File:
- 135463-81-9.mol
Boiling point | 634.1±55.0 °C(Predicted) |
---|---|
Density | 1.291±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | DMF: 1 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): insol |
form | A crystalline solid |
pka | 12.01±0.20(Predicted) |
color | White to off-white |
InChI | InChI=1S/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23) |
InChIKey | PSPGQHXMUKWNDI-UHFFFAOYSA-N |
SMILES | N1(CC(NC2C3=C(N=C4OC(C)=C(C)C4=2)CCCC3)=O)CCCC1=O |
FDA UNII | V6FL6O5GR7 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS09 |
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Signal word | Warning | |||||||||
Hazard statements | H411 | |||||||||
Precautionary statements | P501-P273-P391 | |||||||||
NFPA 704 |
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Coluracetam price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-2196 | Coluracetam 99.87% | 135463-81-9 | 10mg | $60 | 2021-12-16 | Buy |
ApexBio Technology | B1158 | Coluracetam | 135463-81-9 | 10mg | $79 | 2021-12-16 | Buy |
ChemScene | CS-2196 | Coluracetam 99.87% | 135463-81-9 | 50mg | $80 | 2021-12-16 | Buy |
ChemScene | CS-2196 | Coluracetam 99.87% | 135463-81-9 | 5mg | $50 | 2021-12-16 | Buy |
ChemScene | CS-2196 | Coluracetam 99.87% | 135463-81-9 | 100mg | $90 | 2021-12-16 | Buy |
Coluracetam Chemical Properties,Uses,Production
Uses
Copiracetam can be used as a nootropic drug to treat memory and intellectual impairments caused by senile dementia, mild to moderate vascular dementia, trauma and other diseases, and to promote children's intellectual development; it also has antidepressant effects.
Pharmacology
Copiracetam has the ability to improve cognition by participating in the HACU process, increasing the rate-limiting step of synaptic intake of choline to synthesize the neurotransmitter acetylcholine, and increasing the activity of cholinergic neurons.
in vitro
Coluracetam (10(-10)-10(-6) moll), also known as MKC-231, significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding.
in vivo
Oral administration of MKC-231 (Coluracetam; 1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested.
Coluracetam Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Langyou International Trading Co., Ltd | +86-18874586545 +86-18874586545 | linda@xrdchem.cn | China | 197 | 58 |
Guangzhou TongYi biochemistry technology Co.,LTD | +8613073028829 | mack@tongyon.com | China | 2996 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12495 | 58 |
Shandong Hanjiang Chemical Co., Ltd | +86-0533-2066820 +8618369939125 | hanson@sdhanjiang.com | China | 1000 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3878 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5895 | 58 |
Hong Kong Excellence Biotechnology Co., Ltd. | ada@sh-teruiop.com | China | 882 | 58 | |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 152 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
View Lastest Price from Coluracetam manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-29 | Coluracetam
135463-81-9
|
US $19.10 / KG | 1KG | 99% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-09-28 | Coluracetam
135463-81-9
|
US $2.00-1.50 / kg | 1kg | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd | ||
2024-09-28 | COLURACETAM
135463-81-9
|
US $108.00-104.00 / Grams | 50Grams | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD |
- Coluracetam
135463-81-9
- US $19.10 / KG
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
- Coluracetam
135463-81-9
- US $2.00-1.50 / kg
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
- COLURACETAM
135463-81-9
- US $108.00-104.00 / Grams
- 99.99%
- Hebei Dangtong Import and export Co LTD