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N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine structure

CAS No.: 55778-02-4

Chemical Name:: N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

Synonyms: WZ 811;CS-567;DK7350;WZ-811; WZ811;WZ 811, >=98%;N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine;N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine;1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl-;N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE;N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)

CBNumber:: CB62518930

Molecular Formula:: C18H18N4

Molecular Weight:: 290.36

MDL Number:: MFCD18086914

MOL File:: 55778-02-4.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Properties

Melting point	192-194℃ (methanol )
Boiling point	493.2±35.0 °C(Predicted)
Density	1.229±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO: ≥7mg/mL
pka	6.55±0.10(Predicted)
form	powder
color	white to tan

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

WGK Germany

HS Code

2933.39.6190

NFPA 704

	0
2		0

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0088	WZ 811 ≥98% (HPLC)	55778-02-4	5mg	$104	2024-03-01	Buy
Sigma-Aldrich	SML0088	WZ 811 ≥98% (HPLC)	55778-02-4	25mg	$397	2023-01-07	Buy
TCI Chemical	W0017	WZ 811	55778-02-4	25MG	$64	2024-03-01	Buy
TCI Chemical	W0017	WZ 811	55778-02-4	100MG	$175	2024-03-01	Buy
Cayman Chemical	13639	WZ 811 ≥95%	55778-02-4	1mg	$19	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML0088	5mg	$104	Buy
SML0088	25mg	$397	Buy
W0017	25MG	$64	Buy
W0017	100MG	$175	Buy
13639	1mg	$19	Buy

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Chemical Properties,Uses,Production

Description

The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4⁺ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC₅₀ = 0.3 nM). It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC₅₀ = 1.2 nM) in cells and blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC₅₀ = 5.2 nM). The effectiveness of WZ811 in animals remains to be elucidated.

Uses

N1,N4-di-2-Pyridinyl-1,4-benzenedimethanamine acts as an inhibitor for the chemokine receptor CXCR4.

References

[1] zhan w, liang z, zhu a, et al. discovery of small molecule cxcr4 antagonists. journal of medicinal chemistry, 2007, 50(23): 5655-5664.
[2] choi w t, duggineni s, xu y, et al. drug discovery research targeting the cxc chemokine receptor 4 (cxcr4). journal of medicinal chemistry, 2011, 55(3): 977-994.

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Preparation Products And Raw materials

Raw materials

Preparation Products

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Suppliers

Global( 119)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22784	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58
InvivoChem	58

View Lastest Price from N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	WZ811 55778-02-4	US $29.00-68.00 / mg		≥95%	10g	TargetMol Chemicals Inc.
	2019-09-04	N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine 55778-02-4	US $5.00 / KG	1KG	99%	1ton	Career Henan Chemical Co

WZ811
55778-02-4
US $29.00-68.00 / mg
≥95%
TargetMol Chemicals Inc.

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine
55778-02-4
US $5.00 / KG
99%
Career Henan Chemical Co

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine Spectrum

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine(55778-02-4)¹HNMR

55778-02-4(N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine)Related Search:

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1,4-Benzenedimethanamine, N1,N4-di-2-pyridinyl- N1,N4-di-2-pyridinyl-1,4-benzenedimethanamine WZ811 WZ 811 N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine WZ 811, >=98% N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine WZ 811 N,N'-(1,4-PHENYLENEBIS(METHYLENE))DIPYRIDIN-2-AMINE N,N'-Di-2-pyridinyl-1,4-benzenedimethanamine N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine) WZ-811; WZ811 CS-567 N-[[4-[(pyridin-2-ylamino)methyl]phenyl]methyl]pyridin-2-amine N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine USP/EP/BP DK7350 Inhibitor,inhibit,WZ811,WZ 811,CXCR,WZ-811,CXC chemokine receptors N,N'-(1,4-Phenylenebis(methylene))bis(pyridin-2-amine) 55778-02-4 Inhibitors