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ARRY-380

ARRY-380 structure

CAS No.: 937265-83-3

Chemical Name:: ARRY-380

Synonyms: CS-523;Arry-830;ARRY-380;ARRY-380-d3;Arry-380, >=98%;HER2-Inhibitor-1;ARRY380; ARRY 380;ARRY-380 (analog );ARRY-380 USP/EP/BP;ARRY-380;ARRY380; ARRY 380

CBNumber:: CB62554080

Molecular Formula:: C29H27N7O4S

Molecular Weight:: 569.63

MDL Number:: MFCD22420817

MOL File:: 937265-83-3.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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ARRY-380 Properties

Density	1.43
storage temp.	Store at -20°C
solubility	≥28.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form	solid
pka	6.34±0.19(Predicted)
color	Light brown to brown
FDA UNII	H32S1659ED

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P305+P351+P338

NFPA 704

	0
2		0

ARRY-380 price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	24186	Arry-380 analog ≥98%	937265-83-3	1mg	$32	2024-03-01	Buy
Cayman Chemical	24186	Arry-380 analog ≥98%	937265-83-3	5mg	$122	2024-03-01	Buy
Cayman Chemical	24186	Arry-380 analog ≥98%	937265-83-3	10mg	$153	2024-03-01	Buy
Cayman Chemical	24186	Arry-380 analog ≥98%	937265-83-3	25mg	$305	2024-03-01	Buy
TRC	A774000	6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine	937265-83-3	1mg	$70	2021-12-16	Buy

Product number	Packaging	Price	Buy
24186	1mg	$32	Buy
24186	5mg	$122	Buy
24186	10mg	$153	Buy
24186	25mg	$305	Buy
A774000	1mg	$70	Buy

ARRY-380 Chemical Properties,Uses,Production

Description

Arry-380 analog was designed as an inhibitor of EGFR (ErbB1).

Uses

Labelled ARRY-380. ARRY-380 is an orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2.

Uses

ARRY-380 is a potent and selective HER2 inhibitor with IC50 of 8 nM and also inhibits EGFR with IC50 of 4 μM.

target

p95-HER2

References

[1] s. l. moulder, v. borges, s. k. l. chia, t. baetz, e. barrett, j. garrus, k. guthrie, c. kass, e. laird, j. lyssikatos, f. marmsater, e. wallace. arry-380, a selective her2 inhibitor: from drug design to clinical evaluation. poster of aacr-nci-eortc, nov 12-16, 2011, san francisco, ca.
[2] victoria dinkel, deborah anderson, shannon winski, jim winkler, kevin koch and patrice lee. arry-380, a potent, small molecule inhibitor of erbb2, increases survival in intracranial erbb2+ xenograft models in mice. poster available at www.arraybiopharma.com
[3] s. chia, t. baetz, s. d'aloisio, g. fernetich, b. freeman, e. barrett, c. kass, j. kang, b. sajan, s. moulder, and j. garrus. a phase 1 study to assess the safety, tolerability and pharmacokinetics of arry-380 – an oral inhibitor of her2. cancer res 2009;69(24 suppl):abstract nr 5111.

ARRY-380 Preparation Products And Raw materials

Raw materials

Preparation Products

ARRY-380 Suppliers

Global( 96)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22854	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei xin bonus chemical co. LTD	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

View Lastest Price from ARRY-380 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	ARRY-380 (analog ) 937265-83-3	US $30.00-68.00 / mg		98.22%	10g	TargetMol Chemicals Inc.
	2024-10-22	ARRY-380 937265-83-3	US $1.00 / g	1g	Min98%	100kgs	Career Henan Chemica Co

ARRY-380 (analog )
937265-83-3
US $30.00-68.00 / mg
98.22%
TargetMol Chemicals Inc.

ARRY-380
937265-83-3
US $1.00 / g
Min98%
Career Henan Chemica Co

ARRY-380 Spectrum

ARRY-380(937265-83-3)¹HNMR

937265-83-3(ARRY-380)Related Search:

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PLX4032

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ARRY-380 (analog ) Arry-830 ARRY-380;ARRY380; ARRY 380 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a] Arry-380, >=98% ARRY-380 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine HER2-Inhibitor-1 6-[5-[[[2-(Methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-4-quinazolinamine ARRY 380 ARRY-380-d3 N-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-Methylphenyl)-6-(5-(((2-(Methylsulfonyl)ethyl)aMino)Methyl)furan-2-yl)quinazolin-4-aMine CS-523 ARRY380; ARRY 380 6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]quinazolin-4-amine 4-Quinazolinamine, 6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-N-[3-methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]- ARRY-380 USP/EP/BP ARRY-380 (analog ), 10 mM in DMSO 937265-83-3 C29H27N7O4S Inhibitors Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds