ChemicalBook >> CAS DataBase List >>2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one structure

CAS No.: 1013916-37-4

Chemical Name:: 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

Synonyms: Palbociclib intermediates;-5-methyL;oro-8-cycL;3-d]pyriMidin-7(8H)-one;Palbociclib Impurity 105;Palbociclib Intermediate2;2-chloro-8-cyclopentyl-5-Me;Palbociclib impurity 703-201;pyrido[2,3-d]pyrimidin-7(8H)-one;2-chloro-8-cyclopentyl-5-Methylpyrido[2

CBNumber:: CB62554161

Molecular Formula:: C13H14ClN3O

Molecular Weight:: 263.72

MDL Number:: MFCD13181207

MOL File:: 1013916-37-4.mol

Last updated:2024-08-13 17:19:14

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2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Properties

Melting point	176 - 178°C
Boiling point	428.0±34.0 °C(Predicted)
Density	1.346±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	0.82±0.20(Predicted)
color	Yellow to Dark Yellow
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C13H14ClN3O/c1-8-6-11(18)17(9-4-2-3-5-9)12-10(8)7-15-13(14)16-12/h6-7,9H,2-5H2,1H3
InChIKey	BSKNQSYIDZUXQT-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C2C(C)=CC(=O)N(C3CCCC3)C2=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

NFPA 704

	1
2		0

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	H54363	2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%	1013916-37-4	1g	$176.65	2024-03-01	Buy
Alfa Aesar	H54363	2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%	1013916-37-4	5g	$697.65	2024-03-01	Buy
Alfa Aesar	H54363	2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one, 97%	1013916-37-4	250mg	$55.65	2024-03-01	Buy
TRC	C585608	2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one	1013916-37-4	1g	$90	2021-12-16	Buy
Matrix Scientific	131623	2-Chloro-8-cyclopentyl-5-methylpyrido-[2,3-d]pyrimidin-7(8H)-one 97%	1013916-37-4	25g	$147	2021-12-16	Buy

Product number	Packaging	Price	Buy
H54363	1g	$176.65	Buy
H54363	5g	$697.65	Buy
H54363	250mg	$55.65	Buy
C585608	1g	$90	Buy
131623	25g	$147	Buy

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Chemical Properties,Uses,Production

Description

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one is used as an intermediate for Palbociclib, a CDK 4/6 inhibitor used to treat patients with hormone receptor (HR)-positive, HER-2-negative advanced or metastatic (cancer that has spread) breast cancer.

Uses

2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one is used as pharmaceutical intermediate.

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one synthesis

Synthesis of 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one from 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine and TRANS-2-BUTENOIC ACID

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Suppliers

Global( 286)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemExpress	+86-021-58950125 +86-021-58950125;	info@chemexpress.com	China	782	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21628	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58

Supplier	Advantage
ChemExpress	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Shanghai Yingrui Biopharma Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Jinan Carbotang Biotech Co.,Ltd.	58

View Lastest Price from 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-03-04	Palbociclib Impurity 9 1013916-37-4	US $0.00-0.00 / mg	10mg	98%	500mg	ShenZhen H&D Pharmaceutical Technology Co., LTD
2022-05-12	2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1013916-37-4	US $0.00 / g	10g	99.0%	10tons	Wuhan Godbullraw Chemical Co.,ltd
2019-07-06	2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 1013916-37-4	US $100.00 / KG	1KG	98%	100KG	Career Henan Chemical Co

Palbociclib Impurity 9
1013916-37-4
US $0.00-0.00 / mg
98%
ShenZhen H&D Pharmaceutical Technology Co., LTD

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
1013916-37-4
US $0.00 / g
99.0%
Wuhan Godbullraw Chemical Co.,ltd

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
1013916-37-4
US $100.00 / KG
98%
Career Henan Chemical Co

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Spectrum

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one(1013916-37-4)¹HNMR

1013916-37-4(2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one)Related Search:

4-[6-[(8-cyclopentyl-6-ethenyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinecarboxylic acid tert-butyl ester 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butyl 4-(6-((6-(1-butoxyvinyl)-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 2-Amino-5-bromopyridine Palbociclib Impurity 7

4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Pyrido[2,3-d]pyriMidin-7(8H)-one, 8-cyclopentyl-5-Methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]aMino]- Phosphine oxide, tris (2-methylphenyl)- tert-butyl 4-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester

5-(piperazin-1-yl)pyridin-2-aMine 571188-59-5 8-cyclopentyl-6-(1-hydroxyethyl)-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one 1,4-bis(4-nitrophenyl)piperazine 1-(5-Nitropyridin-2-yl)piperazine

6-broMo-8-cyclopentyl-5-Methyl-2-(5-(piperazin-1-yl)pyridin-2-ylaMino)pyrido[2,3-d]pyriMidin-7(8H)-one

1of4

2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one Pyrido[2,3-d]pyriMidin-7(8H)-one, 2-chloro-8-cyclopentyl-5-Methyl- 2-chloro-8-cyclopentyl-5-Me Palbociclib Intermediate2 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (For Palbociclib) 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one 2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one 2-chloro-8-cyclopentyl-5-Methylpyrido[2 3-d]pyriMidin-7(8H)-one 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one oro-8-cycL pyrido[2,3-d]pyrimidin-7(8H)-one 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one,97% -5-methyL 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 2- 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-... Palbociclib Impurity 105 Palbociclib intermediates 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d] 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMi 2-chloro-8-cyclopentyl-5-methoyrido-8H-pyrido[ 2,3-D]pyrimidin- 7 - one 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3- 2-chloro-8-cyclopentyl-5-methyl-8H-pyrido [2,3-D] pyridine Palbociclib impurity 703-201 1013916-37-4 Anticancer 1013916-37-4