ChemicalBook >> CAS DataBase List >>Azelastine
Azelastine
- CAS No.
- 58581-89-8
- Chemical Name:
- Azelastine
- Synonyms
- -4-yl)-;AZELASTINE;SPBio_000657;KBio3_002992;CAS 790307-93-0;Azelastine base;Spectrum3_001984;Spectrum2_000649;Azeptin：Rhino1ast;Azelastine USP/EP/BP
- CBNumber:
- CB6256007
- Molecular Formula:
- C22H24ClN3O
- Molecular Weight:
- 381.9
- MDL Number:
- MFCD00242781
- MOL File:
- 58581-89-8.mol
Last updated:2024-11-20 11:41:24
| Melting point | 111 - 115°C |
|---|---|
| Boiling point | 533.9±60.0 °C(Predicted) |
| Density | 1.1505 (rough estimate) |
| refractive index | 1.5790 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly) |
| pka | pKa 9.82(H2O t=25 I=0.025) (Uncertain) |
| form | Solid |
| color | White to Off-White |
| BCS Class | 1? |
| Stability | Stable under recommended storage conditions., Stable Under Recommended Storage C |
| CAS DataBase Reference | 58581-89-8(CAS DataBase Reference) |
| FDA UNII | ZQI909440X |
| ATC code | R01AC03,R06AX19,S01GX07 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H312-H302-H335-H332 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81 |
Azelastine price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A767410 | Azelastine | 58581-89-8 | 2.5g | $610 | 2021-12-16 | Buy |
| TRC | A767410 | Azelastine | 58581-89-8 | 100mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC130471 | 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride | 58581-89-8 | 250mg | $145 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC130471 | 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride | 58581-89-8 | 100mg | $72 | 2021-12-16 | Buy |
| AK Scientific | C809 | Azelastine | 58581-89-8 | 1g | $617 | 2021-12-16 | Buy |
Azelastine Chemical Properties,Uses,Production
Description
Azelastine has potent, long-lasting histamine H1-receptor blocking activity and several other interesting anti-inflammatory properties related to its antiallergic efficacy .
Uses
anesthetic, anticonvulsant
Definition
ChEBI: A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.
brand name
Astelin (Medpointe); Optivar (Medpointe).
Clinical Use
Azelastine, although not a close structural analogue to the benzimidazoles, has some structural similarities to them. It is used as a nasal spray for allergic rhinitis and as eye drops for allergic conjunctivitis.Like olopatadine, azelastine also stabilizes mast cells, preventing degranulation and subsequent release of histamine, leukotrienes, and PGD2. It is available in Europe for systemic use in the treatment of asthma and seasonal allergies. Besides antihistaminic effects, it also may block release of histamine and other inflammatory mediators from mast cells. When administered orally, the N-dealkylated metabolite appears to contribute significantly to its pharmacological effects.
Safety Profile
Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and Cl- .
Azelastine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 151)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5978 | 58 |
View Lastest Price from Azelastine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-27 | Azelastine
58581-89-8
|
US $0.00 / g/Bag | 10g | 98%min | 120kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-11-19 | Azelastine
58581-89-8
|
US $50.00 / mg | 99.35% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | Azelastine
58581-89-8
|
US $50.00 / mg | 99.35% | 10g | TargetMol Chemicals Inc. |
-
- Azelastine
58581-89-8
- US $0.00 / g/Bag
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Azelastine
58581-89-8
- US $50.00 / mg
- 99.35%
- TargetMol Chemicals Inc.
-
- Azelastine
58581-89-8
- US $50.00 / mg
- 99.35%
- TargetMol Chemicals Inc.
58581-89-8(Azelastine)Related Search:
1of4
1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin
4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinon
4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1-one
4-[(4-chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)-1-phthalazinone
4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one
Azelastinum [INN-Latin]
KBio3_002992
SPBio_000657
Spectrum2_000649
Spectrum3_001984
-4-yl)-
AZELASTINE
1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-
4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one
CAS 790307-93-0
Azeptin：Rhino1ast
2-(Hexahydro-1-methyl-1H-azepin-4-yl)-4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one
4-(p-Chlorobenzyl)-2-(1-methylhexahydro-1H-azepin-4-yl)phthalazin-1(2H)-one
4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone
Azelastine & Azelastine Hydrochloride
Azelastine base
4-[(4-chlorophenyl)Methyl]-2-[(4S)-1-Methylazepan-4-yl]-1,2-dihydrophthalazin-1-one
4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-y1)-1(2H)-phthalazinone
4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one
4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2
4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methyl-4-azepanyl]-1-phthalazinone
Azelastine USP/EP/BP
Phenylpyruvic Acid Impurity 7
58581-89-8
53408-27-6
C22H26ClN3O
TELAZOL
API