Fosravuconazole L-lysine ethanolate
- CAS No.
- 914361-45-8
- Chemical Name:
- Fosravuconazole L-lysine ethanolate
- Synonyms
- E-1224 L-lysine ethanolate;BMS-379224 L-lysine ethanolate;Fosravuconazole L-lysine ethanolate;L-Lysine, coMpd. with 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-1-Methyl-2-[(phosphonooxy)Methoxy]-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile and ethanol (1:1:1) (9CI);(S)-2,6-Diaminohexanoic acid (((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl)oxy)methyl dihydrogen phosphate and ethanol salt;Fungal,onychomycosis,Fosravuconazole Llysine ethanolate,Parasite,parasitemia,inhibit,Fosravuconazole L lysine ethanolate,antifungal,Ravuconazole,Inhibitor,candidiasis,Fosravuconazole L-lysine
- CBNumber:
- CB62563389
- Molecular Formula:
- C31H40F2N7O8PS
- Molecular Weight:
- 739.73
- MDL Number:
- MFCD33402307
- MOL File:
- 914361-45-8.mol
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : 50 mg/mL (67.59 mM; Need ultrasonic)| (insoluble) |
| form | Solid |
| color | White to yellow |
| Water Solubility | Water : < 0.1 mg/mL (ultrasonic) |
| FDA UNII | QC4G8XS0H0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Fosravuconazole L-lysine ethanolate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0145609 | Fosravuconazole(L-lysineethanolate) 96.30% | 914361-45-8 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0145609 | Fosravuconazole(L-lysineethanolate) 96.30% | 914361-45-8 | 10mg | $500 | 2021-12-16 | Buy |
| ChemScene | CS-0145609 | Fosravuconazole(L-lysineethanolate) 96.30% | 914361-45-8 | 25mg | $950 | 2021-12-16 | Buy |
| ChemScene | CS-0145609 | Fosravuconazole(L-lysineethanolate) 96.30% | 914361-45-8 | 50mg | $1550 | 2021-12-16 | Buy |
| ChemScene | CS-0145609 | Fosravuconazole(L-lysineethanolate) 96.30% | 914361-45-8 | 100mg | $2350 | 2021-12-16 | Buy |
Fosravuconazole L-lysine ethanolate Chemical Properties,Uses,Production
Uses
Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a proagent of Ravuconazole, is an orally active broad spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used for candidiasis, onychomycosis and parasitemia research[1][2][3].
Biological Activity
Fosravuconazole L-lysine ethanolate (BMS-379224 L-lysine ethanolate), a prodrug of Ravuconazole, is an orally active broad-spectrum antifungal agent. Fosravuconazole L-lysine ethanolate can be used in the study of candidiasis, onychomycosis and parasitic diseases.
in vitro
Fosravuconazole has potent in vitro antifungal activity against a wide range of fungal species, including Candida , Aspergillus , and Trichophyton species .
in vivo
Fosravuconazole (E-1224; 10-50 mg/kg; oral administration; daily; for 20 days) treatment suppresses the parasitemia and prevents death in mice infected with the T. cruzi Y strain.
| Animal Model: | Swiss female mice (20-24 g) inoculated with trypomastigotes (Y strain). |
| Dosage: | 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg , 50 mg/kg |
| Administration: | Oral administration; daily; for 20 days |
| Result: | Suppressed the parasitemia and prevented death. |
References
[1] Shinichi Watanabe, et al. Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: A multicenter, double-blind, randomized phase III study. J Dermatol. 2018 Oct;45(10):1151-1159. DOI:10.1111/1346-8138.14607
[2] Katsura Hata, et al. Development of E1224 by leveraging a strategic partnership for the medicines creation against neglected tropical diseases. Parasitol Int. 2020 Dec 25;81:102278. DOI:10.1016/j.parint.2020.102278
[3] Lívia de Figueiredo Diniz, et al. Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice. Antimicrob Agents Chemother. 2018 May 25;62(6):e00401-18. DOI:10.1128/AAC.00401-18
Fosravuconazole L-lysine ethanolate Preparation Products And Raw materials
Fosravuconazole L-lysine ethanolate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
| Shanghai eliv pharmaceutical Co.,Ltd. | 021-50158063 | sales@elivpharma.com | China | 511 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9342 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4195 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 10000 | 58 |
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