PiMobendan (hydrochloride)
- CAS No.
- 77469-98-8
- Chemical Name:
- PiMobendan (hydrochloride)
- Synonyms
- PiMobendan (hydrochloride);4,5-Dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methyl-3(2H)-pyridazinone monohydrochloride
- CBNumber:
- CB62682019
- Molecular Formula:
- C19H19ClN4O2
- Molecular Weight:
- 370.83276
- MDL Number:
- MFCD05900557
- MOL File:
- 77469-98-8.mol
Melting point | 311°(dec) |
---|---|
storage temp. | Store at -20°C |
solubility | Soluble in DMSO |
form | Powder |
FDA UNII | 7595Q8C89H |
PiMobendan (hydrochloride) price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ApexBio Technology | B1165 | Pimobendanhydrochloride | 77469-98-8 | 5mg | $125 | 2021-12-16 | Buy |
Crysdot | CD31000820 | Pimobendanhydrochloride 98+% | 77469-98-8 | 10mg | $167 | 2021-12-16 | Buy |
Chemenu | CM110660 | Pimobendanhydrochloride 98% | 77469-98-8 | 50mg | $473 | 2021-12-16 | Buy |
Crysdot | CD31000820 | Pimobendanhydrochloride 98+% | 77469-98-8 | 50mg | $505 | 2021-12-16 | Buy |
Crysdot | CD31000820 | Pimobendanhydrochloride 98+% | 77469-98-8 | 5mg | $89 | 2021-12-16 | Buy |
PiMobendan (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
Pimobendan hydrochloride (UD-CG115 hydrochloride) is a selective inhibitor of PDE3 with IC50 of 320 nM.
in vitro
Pimobendan hydrochloride (UD-CG115 hydrochloride) exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC 50 of 0.32 uM compared to the inhibition of PDE I and PDE II ( IC 50 >30 μM). In human atrial cells, 100 μM Pimobendan (UD-CG115) significantly increases the L-type calcium current (ICa(L)) (evoked by depolarization to +10 mV from a holding potential of -40 mV) by 250.4% with the half-maximal stimulation (EC 50 ) of 1.13 μM. In rabbit atrial cells, Pimobendan (UD-CG115) increases ICa(L) at +10 mV by 67.4.%, which is significantly lower than that obtained in human atrial cells.
in vivo
Pimobendan (UD-CG115) shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. Administration of Pimobendan (UD-CG115) significantly increases the final survival rate from 33.6% (control) to 53.3% (0.1 mg/kg) or 66.7% (1 mg/kg). It (UD-CG115) (1 mg/kg) also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. Pimobendan (UD-CG115) suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production.
PiMobendan (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
PiMobendan (hydrochloride) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | sales@regentsciences.com | China | 9296 | 58 |
Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |